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Worse problems with SARS-CoV-2 variants may be on the way


Worse problems with SARS-CoV-2 variants may be on the way
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronavirus disease (COVID-19), continues to spread globally.  
With this spread, new variants and strains have emerged, posing a threat to the recently developed and distributed SARS-CoV-2 vaccines efficacy.
Researchers at the Department of Integrative Biomedical Sciences, University of Cape Town, South Africa, found evidence of a significant change in the selective forces acting on immunologically important SARS-CoV-2 genes, such as N and S. These likely coincided with the emergence of the 501Y lineages.
In the study, published in the pre-print server ....

United States , South Africa , University Of Cape Town , Western Cape , South African , Angela Betsaidab Laguipo , Department Of Integrative Biomedical Sciences , Angela Betsaida , Integrative Biomedical Sciences , Cape Town , Sars Cov 2 , Amino Acid , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் கேப் நகரம் , மேற்கு கேப் , துறை ஆஃப் ஒருங்கிணைந்த உயிர் மருத்துவ அறிவியல் , ஒருங்கிணைந்த உயிர் மருத்துவ அறிவியல் , கேப் நகரம் , அமினோ அமிலம் , கொரோனா வைரஸ் , சர்வதேச பரவல் ,

Self-assembling nanoparticles an effective vaccine candidate for SARS-CoV-2

New research project aims to treat patients with secondary brain damage


New research project aims to treat patients with secondary brain damage
The Universities of Birmingham and Cambridge have launched a new research project aimed at discovering if selective P2X7 receptor blocker drugs can be repurposed to treat patients with secondary brain damage.
Funded by almost £1 million from the Medical Research Council, the project will be carried out in two phases over the next three years.
The leading cause of death and disability in those aged under 40, traumatic brain injury costs the UK economy an estimated £8 billion per year. Mortality rates are high and many who survive suffer life-long disability, however there are currently no approved drugs available in the clinic to reduce the impact of such injuries on patients. ....

United Kingdom , Nicholas Barnes , Adel Helmy , Peter Hutchinson , Emily Henderson , University Of Cambridge , School Of Pharmacy , University Of Birmingham , Research Council , Medical Research Council , Study Principal Investigator , Professor Tony Belli , Professor Peter Hutchinson , Medical Research , Research Project , Social Care , Traumatic Brain Injury , ஒன்றுபட்டது கிஂக்டம் , நிக்கோலஸ் களஞ்சியங்கள் , பீட்டர் ஹட்சின்சன் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , பள்ளி ஆஃப் மருந்தகம் , பல்கலைக்கழகம் ஆஃப் பர்மிங்காம் , ஆராய்ச்சி சபை , மருத்துவ ஆராய்ச்சி சபை ,

CAR T-cell therapy triples expected length of remission for relapsed multiple myeloma patients


CAR T-cell therapy triples expected length of remission for relapsed multiple myeloma patients
A new type of CAR T-cell therapy more than triples the expected length of remission for multiple myeloma patients who have relapsed several times, according to an international clinical trial with UT Southwestern as the lead enrolling site.
Results of the trial, published recently in the
New England Journal of Medicine, were significantly better than those seen with other therapies available to heavily relapsed and refractory myeloma patients who had already received the three main classes of treatment. Nearly three-quarters of the patients had at least a partial response to the therapy. About a third achieved a complete remission, with the disappearance of all traces of cancer. ....

United States , Larryd Anderson Jr , Emily Henderson , Haroldc Simmons Comprehensive Cancer Center , Drug Administration , Bristol Myers Squibb , New England Journal , Comprehensive Cancer Center , African American , Associate Professor , Internal Medicine , Multiple Myeloma , T Cell , Clinical Trial , Immune System , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பிரிஸ்டல் மைஸ் ஸ்க்விப்ப் , புதியது இங்கிலாந்து இதழ் , விரிவான புற்றுநோய் மையம் , இணை ப்ரொஃபெஸர் , உள் மருந்து , பல மைலோமா , டி செல் , மருத்துவ சோதனை , நோய் எதிர்ப்பு சக்தி அமைப்பு ,

Researchers find new way to prevent attention deficits associated with Fragile X syndrome


Researchers find new way to prevent attention deficits associated with Fragile X syndrome
Mount Sinai Researchers find a new way to prevent attention deficits associated with Fragile X, a leading genetic cause of autism, in an animal model.
Corresponding author:
Hirofumi Morishita, MD, Ph.D., Department of Psychiatry, Neuroscience, Friedman Brain Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York.
Bottom line:
The adolescent maturation of the frontal cortex is important for establishing cognitive function, and disruption of this process is associated with neurodevelopmental disorders.
This study uncovered a new molecular driver of frontal circuit maturation that is essential for cognitive function, and demonstrated, in an animal model, that this mechanism can be targeted to restore attention deficits caused by a leading genetic cause of autism. ....

New York , United States , Hirofumi Morishita , Emily Henderson , Icahn School Of Medicine At Mount Sinai , Mount Sinai School Of Medicine , Development Institute , Mindich Child Health , Friedman Brain Institute , Department Of Psychiatry , Sinai Researchers , Icahn School , Mount Sinai , Mount Sinai School , Animal Model , Child Health , Cognitive Function , Fragilex Syndrome , Mouse Model , Top Down , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ஹிரோபூமி மோரிஷிதா , எமிலி ஹென்டர்சன் , இக்ஹ்ன் பள்ளி ஆஃப் மருந்து இல் ஏற்ற சினை , ஏற்ற சினை பள்ளி ஆஃப் மருந்து ,