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Researchers present fragment-based computational design of antibodies that target structured epitopes

A new study describes a novel fragment-based method to design antibody complementarity determining region (CDR) loops. ....

Ramya Dwivedi , Protein Data Bank , Corona Borealis Studio , Coronavirus Disease Covid 19 , Sars Cov 2 , Antibody Discovery , Corona Virus , In Vitro , Infection Control , Spike Protein , ரம்யா டுவிவேடி , ப்ரோடீந் தகவல்கள் வங்கி , கொரோனா போரியாலிஸ் ஸ்டுடியோ , சர்வதேச பரவல் , ஆன்டிபாடி கண்டுபிடிப்பு , உயிரி தொழில்நுட்பவியல் , கொரோனா வைரஸ் , இல் விட்ரோ , தொற்று கட்டுப்பாடு , ஸ்பைக் ப்ரோடீந் ,

Study rethinks the role of ACE2 in SARS-CoV-2 viral entry

Researchers in the US recently infected a series of human lung and head/neck cancer cell lines with SARS-CoV-2 that expressed varying levels of ACE2 and the TMPRSS2 protease to reassess their role in viral entrance. ....

Susha Cheriyedath , Washington University , Sequence Read Archive , Image Credit , Cell Culture , Coronavirus Disease Covid 19 , Sars Cov 2 , Cell Line , Corona Virus , In Vitro , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , வாஷிங்டன் பல்கலைக்கழகம் , வரிசை ரெட் காப்பகம் , படம் கடன் , செல் கலாச்சாரம் , செல் வரி , கொரோனா வைரஸ் , இல் விட்ரோ , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Using decision theory for precise choice of breast cancer treatment

Using decision theory for precise choice of breast cancer treatment
The precise choice of treatment for breast cancer depends upon the status of the hormone receptors (for estrogen and progesterone). Their conventional determination by means of immunohistochemistry (IHC) is associated with a certain error rate, which can be reduced by adding genomic data.
Even conventional statistics can bring about a notable improvement but now it is possible to use decision theory to optimally combine diagnostic findings, particularly where they are contradictory.
This is the finding of a recent study conducted by MedUni Vienna under the leadership of Wolfgang Schreiner from the Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS). ....

Wolfgang Schreiner , Cacsire Castillo , Emily Henderson , Meduni Vienna Division , University Of Vienna , Meduni Vienna , Medical Statistics , Intelligent Systems , General Gynecology , Gynecologic Oncology , Medical University , Big Data , Christian Singer , Cacsire Castillo Tong , Standard Operating Procedures , Breast Cancer , Gene Expression , ஓநாய் ஸ்ச்சிரேனேற் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் வியன்னா , மருத்துவ புள்ளிவிவரங்கள் , புத்திசாலி அமைப்புகள் , ஜநரல் பெண்ணோயியல் , பெண்ணோயியல் புற்றுநோயியல் , மருத்துவ பல்கலைக்கழகம் , பெரியது தகவல்கள் ,

Experimental safety switch reduces severity of CAR-T immunotherapy-related side effects

Experimental safety switch reduces severity of CAR-T immunotherapy-related side effects
UNC Lineberger Comprehensive Cancer Center researchers have successfully used an experimental safety switch, incorporated as part of a chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy, to reduce the severity of treatment side effects that sometimes occur. This advance was seen in a patient enrolled in a clinical trial using CAR-T to treat refractory acute B-cell leukemia. It demonstrates a proof-of-principle for possible expanded use of CAR-T immunotherapy paired with the safety switch.
The researchers published their findings in the journal
Blood as an ahead-of-print publication.
With CAR-T therapy, T-cells from a patient s immune system are modified in a manufacturing facility to express part of an antibody that can bind to a surface protein on cancer cells. The modified T-cells, after being infused back into the patient, seek out and attack cancer ce ....

Matthew Foster , Jonathan Serody , Emily Henderson , Lineberger Cellular Immunotherapy Program , Cellular Immunotherapy Program , Lineberger Cellular Therapy Program , School Of Medicine , Bellicum Pharmaceuticals , Lineberger Comprehensive Cancer Center , Comprehensive Cancer Center , Gianpietro Dotti , Cellular Therapy , Acute Lymphoblastic Leukemia , Chimeric Antigen Receptor , Clinical Trial , Immune System , T Cell , மேத்யூ வளர்ப்பு , எமிலி ஹென்டர்சன் , லிநேபேர்கேற் செல்லுலார் நோயெதிர்ப்பு சிகிச்சை ப்ரோக்ர்யாம் , செல்லுலார் நோயெதிர்ப்பு சிகிச்சை ப்ரோக்ர்யாம் , லிநேபேர்கேற் செல்லுலார் சிகிச்சை ப்ரோக்ர்யாம் , பள்ளி ஆஃப் மருந்து , லிநேபேர்கேற் விரிவான புற்றுநோய் மையம் , விரிவான புற்றுநோய் மையம் , செல்லுலார் சிகிச்சை ,

Innovative cancer treatment effective in combating fungal infection in vitro and in mice

Innovative cancer treatment effective in combating fungal infection in vitro and in mice
An innovative cell-based treatment for cancer has been found promising for the control of infections caused by fungi. A study published in the journal
Cytotherapy reports that the use of CAR (chimeric antigen receptor) T-cells programmed to recognize
Cryptococcus spp. fungi was effective in combating infection in vitro and in mice.
C. gattii and
C. neoformans are present in soil with dead organic matter and places contaminated by the droppings of pigeons and other birds. They cause systemic mycoses in the human organism. They can infect the lungs and central nervous system, causing meningitis or meningoencephalitis. The symptoms vary according to the site of the infection, which can be fatal. Transmission occurs by inhalation of the fungi. ....

United States , Bioagents Biocel , Paulo Ribeir , Emily Henderson , Department Of Cellular , Preto Medical School , Dissemination Center , Us Centers For Disease , Drug Administration , Md Anderson Cancer Center , Disease Control , Thiago Aparecido , Molecular Biology , Pathogenic Bioagents , Brazilian Researcher , Young Investigator , Cancer Center , Cell Based Therapy , Cancer Treatment , Cell Wall , Central Nervous System , Chimeric Antigen Receptor , Cryptococcal Meningitis , Immune Response , In Vitro , Nervous System ,