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Researchers develop mutant gene-targeted immunotherapy approach to fight cancers


Researchers develop mutant gene-targeted immunotherapy approach to fight cancers
A novel targeted immunotherapy approach developed by researchers at the Ludwig Center, the Lustgarten Laboratory, and Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center employs new antibodies against genetically altered proteins to target cancers.
The researchers targeted their immunotherapy approach to alterations in the common cancer-related p53 tumor suppressor gene, the RAS tumor-promoting oncogene or T-cell receptor genes. They also tested the therapy on cancer cells in the laboratory and in animal tumor models. Their findings are reported in three related studies published March 1 in
Science Immunology, ....

Emily Han , Emily Henderson , Bert Vogelstein , Suman Paul , Kenneth Kinzler , Katharine Wright , Alex Pearlman , Jacqueline Douglass , Sandra Gabelli , Johns Hopkins , Chung Hsiue , Bloomberg Kimmel Institute For Cancer Immunotherapy , Johns Hopkins Kimmel Cancer Center , Ludwig Center , Experimental Therapeutics For The Ludwig Center , Johns Hopkins University School Of Medicine , Howard Hughes Medical Institute , Lustgarten Laboratory , Kimmel Institute , Science Immunology , Science Translational , Johns Hopkins University School , Emily Han Chung Hsiue , Johns Hopkins Report , Senior Author , Associate Professor ,

NYU Oral Cancer Center receives $3.1 million grant to explore the interplay between nerves and cancer


NYU Oral Cancer Center receives $3.1 million grant to explore the interplay between nerves and cancer
NYU Oral Cancer Center has been awarded a five-year, $3.1 million grant (R01 CA231396) by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH). The principal investigators, Donna Albertson, PhD, and Brian Schmidt, DDS, MD, PhD, seek to improve oral cancer treatment and alleviate pain by better understanding how a subset of nerves that possess a receptor called TRPV1 on the cell membrane contribute to cancer progression and pain.
Oral cancer patients have a poor prognosis and endure debilitating pain. Albertson and Schmidt have been investigating oral cancer at the molecular level for nearly two decades to address these pressing clinical challenges. ....

Brian Schmidt , Donna Albertson , Emily Henderson , National Cancer Institute , College Of Dentistry , National Institutes Of Health , Oral Cancer Center , Cancer Center , National Institutes , Maxillofacial Surgery , Oral Cancer , Cancer Treatment , Cell Membrane , பிரையன் ஶ்மிட் , டோனா ஆல்பர்ட்சன் , எமிலி ஹென்டர்சன் , தேசிய புற்றுநோய் நிறுவனம் , கல்லூரி ஆஃப் பல் மருத்துவம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , வாய்வழி புற்றுநோய் மையம் , புற்றுநோய் மையம் , தேசிய நிறுவனங்கள் , மக்ஷில்லொபசியல் அறுவை சிகிச்சை , வாய்வழி புற்றுநோய் , புற்றுநோய் சிகிச்சை , செல் சவ்வு ,

Study could offer a new way to treat Type 1 and Type 2 diabetes


Study could offer a new way to treat Type 1 and Type 2 diabetes
Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study. The findings, published online in
PNAS, could offer a new way to treat both Type 1 and Type 2 diabetes in people.
More than 34 million Americans have diabetes, a disease characterized by a loss of beta cells in the pancreas. Beta cells produce insulin, a hormone necessary for cells to absorb and use glucose, a type of sugar that circulates in the blood and serves as cellular fuel. ....

United States , Jyun Wang , Philippe Scherer , Williaml Holland , Emily Henderson , University Of Utah , Diabetes Research , Touchstone Center , May Yun Wang , Blood Sugar , Diabetic Coma , Insulin Resistance , Type 1 Diabetes , Type 2 Diabetes , ஒன்றுபட்டது மாநிலங்களில் , யுன் வாங் , பிலிப் ஸ்கிரெர் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் உட்டா , நீரிழிவு நோய் ஆராய்ச்சி , டச்ஸ்டோன் மையம் , இருக்கலாம் யுன் வாங் , நீரிழிவு நோய் , இரத்தம் சர்க்கரை , நீரிழிவு கோமா , இன்சுலின் எதிர்ப்பு ,