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Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells


Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells
The clinical phenotype of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is remarkable for its wide range of severity among individual patients. Genetic variations are known to mediate part of these differences.
To examine these differences, researchers in a new study used human induced pluripotent stem cells (iPSCs) from different genetically diverse individuals. These cells are used to model genetic disease since they contain the donor’s genetic information.
The study, published as a preprint on the
bioRxiv server, uses a panel of iPSCs from over 500 individuals. The researchers preferred undifferentiated iPSCs to reduce the time required to differentiate them, especially since infection is not always reliable. ....

Liji Thomas , Image Credit , Sars Cov 2 , Stem Cells , Angiotensin Converting Enzyme 2 , Cell Membrane , Corona Virus , Genetic Information , Induced Pluripotent Stem Cells , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , படம் கடன் , தண்டு செல்கள் , செல் சவ்வு , கொரோனா வைரஸ் , ஜெநெடிக் தகவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

Research predicts which mammal species can spread SARS-CoV-2

Scientists worldwide are fighting to contain the ongoing COVID-19 pandemic, which has already claimed more than 2.48 million lives. Preventing spillback infections is essential to containing the pandemic. To do so, it is vital to understand the nature of the virus, i.e., its susceptibility to a range of hosts. ....

Priyom Bose , Image Credit , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Coronavirus Disease Covid 19 , In Vivo , பிரீயோம் போஸ் , படம் கடன் , இல் விவோ , சர்வதேச பரவல் ,