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Fooling the novel coronavirus with a fake handshake to inactivate the virus

Fool the novel coronavirus once and it can't cause infection of cells, new research suggests. ....

United States , Ohio State University , Ross Larue , Amit Sharma , Emily Henderson , Study Co , Study Co Lead Author , Assistant Professor , Veterinary Biosciences , Ohio State , Corona Virus , Sars Cov 2 , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஓஹியோ நிலை பல்கலைக்கழகம் , ரோஸ் லார் , அமித் ஷர்மா , எமிலி ஹென்டர்சன் , படிப்பு இணை , படிப்பு இணை வழி நடத்து நூலாசிரியர் , உதவியாளர் ப்ரொஃபெஸர் , கால்நடை உயிர் அறிவியல் , ஓஹியோ நிலை , கொரோனா வைரஸ் , ஸ்பைக் ப்ரோடீந் ,

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?
Rotavirus is a common diarrheal disease that affects young children. Live oral rotavirus vaccines have been used to reduce its incidence in many countries. However, with the onset of the coronavirus disease 2019 (COVID-19) pandemic, and amid focus on vaccines as the only definitive method of durable control, a new study describes the possibility of producing a combined vaccine against both infections.
The study began with the generation of recombinant (r)SA11 rotaviruses, into which segment 7 modified RNAs were introduced. These encoded sequences for the non-structural protein NSP3 and some parts of the viral spike. ....

Liji Thomas , Indiana University , Expression Platform , Image Credit , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Spike Protein , Structural Protein , இந்தியானா பல்கலைக்கழகம் , வெளிப்பாடு நடைமேடை , படம் கடன் , கொரோனா வைரஸ் , சர்வதேச பரவல் , ஸ்பைக் ப்ரோடீந் , கட்டமைப்பு ப்ரோடீந் ,

Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?

Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?
Common immunization routes for coronavirus disease 2019 (COVID-19) vaccine candidates range from intramuscular, nasal and oral to intradermal.
Now, scientists at the University of Salzburg and Pantec Biosolutions AG have developed a laser-facilitated epicutaneous immunization against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. The model has induced angiotensin-converting enzyme 2 (ACE2) blocking antibodies in mice.
The study, published on the pre-print
bioRxiv server, shows another potential effective route to administer vaccines against SARS-CoV-2, the virus that causes COVID-19. Finding more ways to introduce vaccines can help combat the pandemic. ....

Angela Betsaidab Laguipo , University Of Salzburg , Angela Betsaida , Pantec Biosolutions , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , பல்கலைக்கழகம் ஆஃப் சால்ஸ்பர்க் , சர்வதேச பரவல் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Evolution of the spike gene of SARS-CoV-2 for human adaptation

Evolution of the spike gene of SARS-CoV-2 for human adaptation
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 111 million individuals worldwide and has resulted in the COVID-19 pandemic. Many pangolin and bat-derived viruses are closely related to SARS-CoV-2, which suggests its likely zoonotic origin.
Researchers have found a 96% similarity in nucleotide sequence between bat coronavirus (RaTG13), isolated from
s in China in 2013, and SARS-CoV-2 and ~97% amino acid similarity with the Spike (S) protein. This S protein performs two essential roles, i.e., mediates receptor-binding and membrane fusion. Hence, spike protein is regarded as a key coronavirus determinant of host tropism. ....

Priyom Bose , Middle East , Non Synonymous , Image Credit , West Nile , Sars Cov 2 , Amino Acid , Corona Virus , Coronavirus Disease Covid 19 , Mers Cov , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , பிரீயோம் போஸ் , நடுத்தர கிழக்கு , படம் கடன் , மேற்கு நைல் , அமினோ அமிலம் , கொரோனா வைரஸ் , மேற்ச் கோவ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Proteases modulate SARS-CoV-2 spike protein activation and deactivation

Proteases modulate SARS-CoV-2 spike protein activation and deactivation
Proteases are enzymes that catalyze the break-down of proteins by hydrolysis and are key to the infection process of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike protein that initially interacts with the ACE2 receptor on the surface of host cells must undergo cleavage to initiate a conformational change that allows entry into the cell. Proteolysis can be facilitated, and has been identified to take place, at several stages: by membrane-bound proteases belonging to the host cell, such as TMPRSS2; extracellular proteases, such as furin; or within an endosome following endocytosis by cathepsins B and L, allowing the virus to escape into the cytoplasm. ....

Michael Greenwood , Multiple Sites , Protease Ase Cleavages , Image Credit , Sars Cov 2 , Spike Protein , Amino Acid , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , மைக்கேல் கிரீன்வுட் , பல தளங்கள் , படம் கடன் , ஸ்பைக் ப்ரோடீந் , அமினோ அமிலம் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,