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Some SARS-CoV-2 variants evade mRNA vaccine-induced humoral immune, says study

Why can SARS-CoV-2 infection cause neurological and cardiovascular symptoms?


Why can SARS-CoV-2 infection cause neurological and cardiovascular symptoms?
Research looking at the pathophysiology behind coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is ongoing. A team of researchers from Columbia University Vagelos College of Physicians & Surgeons, USA, present results linking oxidative stress and the activation of a biochemical pathway associated with Alzheimer’s disease to SARS-CoV-2 infection.
“In this study, we propose a potential mechanism that may contribute to systemic organ failure caused by SARS-CoV-2: defective Ca
2+ regulation and its downstream signaling,” wrote the researchers. “Of particular interest is that leaky RyR2 channels in the brain were associated with activation of neuropathological pathways that are also found in the brains of Alzheimer’s Disease patients.” ....

United States , Jocelyn Solis Moreirafeb , Jocelyn Solis Moreira , Columbia University Vagelos College Of Physicians Surgeons , Columbia University Vagelos College , Alzheimer Tau , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Oxidative Stress , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , முதுமறதி டா , கொரோனா வைரஸ் , நோயியல் இயற்பியல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , மன அழுத்தம் ,

Targeting MAPK4 enzyme may be a potential new strategy to combat prostate cancer


Targeting MAPK4 enzyme may be a potential new strategy to combat prostate cancer
The battle against late-stage prostate cancer might have found a potential new strategy to combat this deadly disease. Research led by Baylor College of Medicine reveals in the
Journal of Clinical Investigation that the enzyme MAPK4 concertedly activates androgen receptor (AR) and AKT, molecules at the core of two cellular signaling pathways known to promote prostate cancer growth and resistance to standard therapy.
Importantly, inhibiting MAPK4 simultaneously inactivated both AR and AKT and stopped cancer growth in animal models. The findings open the possibility that targeting MAPK4 in human prostate cancer might provide a novel therapeutic strategy for this disease that is the second leading cause of cancer death in American men. ....

United States , Emily Henderson , Baylor College Of Medicine , Baylor College , Clinical Investigation , Danl Duncan Comprehensive Cancer Center , Prostate Cancer , Medical Research , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பேலர் கல்லூரி ஆஃப் மருந்து , பேலர் கல்லூரி , மருத்துவ விசாரணை , ப்ராஸ்டேட் புற்றுநோய் , மருத்துவ ஆராய்ச்சி ,

O-glycosylation of SARS-CoV-2 spike protein in insect and human cell lines


O-glycosylation of SARS-CoV-2 spike protein in insect and human cell lines
Sites of O-glycosylation on the spike protein were near N-glycosites, suggesting O-glycans complement N-glycans effect in immune shielding.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 pandemic, has some characteristics that were not seen before in human coronaviruses, such as mutation on the receptor-binding domain (RBD) for high affinity to the human angiotensin-converting enzyme 2 (ACE2) and presence of a furin cleavage site between the two subunits of the spike protein.
Several vaccines have now been approved for use, and many more are under clinical trials. Some vaccines are subunit formulations that use recombinant viral proteins for immunization. ....

Lakshmi Supriya , Orbitrap Lumos , Phd Feb , Fusion Lumos , Orbitrap Fusion Lumos , Sars Cov 2 , Spike Protein , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Immune System , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , லட்சுமி சுப்ரியா , ஃப்ட் ஃபெப் , இணைவு லுமோஸ் , ஸ்பைக் ப்ரோடீந் , கொரோனா வைரஸ் , எதிர் மின்னணு , நோய் எதிர்ப்பு சக்தி அமைப்பு , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,