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One dose of SARS-CoV-2 vaccine candidate boosts neutralizing antibody response in COVID-19 convalescents

A new study details the results from a single dose of the FINLAY FR 1A recombinant dimeric receptor-binding domain (RBD) base vaccine during a phase I clinical trial with 30 COVID-19 convalescents to test its capacity for boosting natural immunity. ....

Liji Thomas , Cuban Convalescent Serum Panel , Coronavirus Disease Covid 19 , Sars Cov 2 , Clinical Trial , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , கியூபன் சுறுசுறுப்பான சீரம் குழு , மருத்துவ சோதனை , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Genetic variation associated with COVID-19 outcome

Genetic variation associated with COVID-19 outcome
The severity of outcome from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is widely varied, with most individuals remaining asymptomatic while others experience severe life-threatening pneumonia and multi-organ failure. Host genetics play a role in disease progression and prognosis. A paper recently uploaded to the preprint server
et al. (1
st March 2021) identifies several alleles associated with the gene natriuretic peptide receptor C (NPR3) that may impact disease severity.
How was the study performed?
The group worked with 4,488 high-risk COVID-19 outpatients being over 40 years of age and having at least one other comorbidity such as diabetes or obesity. The group was split into two equal sizes, one of which received a placebo, while the other received 0.5 mg colchicine, an anti-inflammatory, daily for a month. The patients were evaluated for disease symptoms 15 and 30 days into ....

Michael Greenwood , Image Credit , Chromosome 9 , Corona Virus , Coronavirus Disease Covid 19 , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , மைக்கேல் கிரீன்வுட் , படம் கடன் , கொரோனா வைரஸ் , நீரிழிவு நோய் , உடல் பருமன் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Cell surface marker CD47 may allow early diagnosis of severe COVID-19

A new study reports the potential of the cell surface marker, CD47, as a biomarker for hyperinflammation, a characteristic feature of severe COVID-19. ....

Liji Thomas , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Public Health , Pulmonary Hypertension , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Signaling Pathway , கொரோனா வைரஸ் , நீரிழிவு நோய் , உடல் பருமன் , சர்வதேச பரவல் , பொது ஆரோக்கியம் , நுரையீரல் உயர் இரத்த அழுத்தம் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , சமிக்ஞை நடைபாதை ,

Early antibody response predicts COVID-19 outcome

Early antibody response predicts COVID-19 outcome
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus behind the coronavirus disease 2019 (COVID-19) pandemic, has claimed over 2.54 million lives so far and affected more than 114 million people globally. In the U.S. alone, more than 516,000 deaths are attributed to the virus. Neutralizing antibodies targeting the SARS-CoV-2 spike protein are the most widely used candidates for developing vaccines and therapeutics. So far, there have been three Emergency Use Authorizations by the U.S. Food and Drug Administration for such antibodies and combinations, and many others are in the development pipeline.
Studies have shown that the inflammatory phase of COVID-19 is associated with severe disease and acute respiratory distress syndrome. During this phase, macrophages and monocytes are activated, and cytokines are released, leading to a cytokine storm. It may also involve viral transmission independen ....

Susha Cheriyedath , Drug Administration , Emergency Use Authorizations , Early Antibody Responses Associated , Image Credit , Acute Respiratory Distress Syndrome , Corona Virus , Coronavirus Disease Covid 19 , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஆரம்ப ஆன்டிபாடி பதில்கள் தொடர்புடையது , படம் கடன் , எடுப்போசை சுவாச துன்பம் நோய்க்குறி , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Researchers develop ultrapotent miniproteins that target SARS-CoV-2 receptor-binding domain

Researchers have investigated the effectiveness of a bioengineered miniprotein in protecting against SARS-CoV-2 infection in vivo. The researchers evaluated the miniprotein, LCB1, against SARS-CoV-2-mediated lung disease in human ACE2-expressing transgenic mice. ....

South Africa , United States , United Kingdom , Ramya Dwivedi , University Of Washington , Image Credit , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , In Vivo , Lung Disease , Mouse Model , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , ரம்யா டுவிவேடி , பல்கலைக்கழகம் ஆஃப் வாஷிங்டன் , படம் கடன் , கொரோனா வைரஸ் , இல் விவோ , நுரையீரல் நோய் , சுட்டி மாதிரி , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச ,