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Immune dysregulation can affect the efficacy of CAR T therapy in some lymphoma patients

Immune dysregulation can affect the efficacy of CAR T therapy in some lymphoma patients
Chimeric antigen receptor T-cell therapy, or CAR T, has been a breakthrough in the treatment of blood cancers such as acute lymphoblastic leukemia and diffuse large B-cell lymphoma. Clinical studies have shown overall response rates of more than 80% with an ongoing response of nearly 40% more than two years after therapy. However, the cellular immunotherapy doesn t work for every patient.
Moffitt Cancer Center, one of the leading centers for cellular immunotherapy, is researching why some patients have a better CAR T response than others and what can be done to improve the treatment s effectiveness. In a new study published in ....

United States , Frederick Locke , Michael Jain , Emily Henderson , American Society Of Hematology , Cellular Immunotherapy Department At Moffitt , Oncology Program , Cellular Immunotherapy Department , Moffitt Cancer Center , Cancer Center , American Society , Vice Chair , Marrow Transplant , Immuno Oncology Program , Moffitt Cancer , Acute Lymphoblastic Leukemia , Chimeric Antigen Receptor , Hodgkin Lymphoma , Non Hodgkin Lymphoma , T Cell , ஒன்றுபட்டது மாநிலங்களில் , ஃப்ரெடரிக் பூட்டு , மைக்கேல் ஜெயின் , எமிலி ஹென்டர்சன் , அமெரிக்கன் சமூகம் ஆஃப் ஹீமாட்டாலஜி , செல்லுலார் நோயெதிர்ப்பு சிகிச்சை துறை இல் மாஃபிட் ,

Remyelinating drug shows potential to improve vision in patients with MS

Remyelinating drug shows potential to improve vision in patients with MS
A team led by a biomedical scientist at the University of California, Riverside, reports a drug an estrogen receptor ligand called indazole chloride (IndCl) has the potential to improve vision in patients with multiple sclerosis, or MS.
The study, performed on mice induced with a model of MS and the first to investigate IndCl s effect on the pathology and function of the complete afferent visual pathway, is published in
Brain Pathology. The afferent visual pathway includes the eyes, optic nerve, and all brain structures responsible for receiving, transmitting, and processing visual information. ....

United States , Riverside School , Seema Tiwari Woodruff , Johna Katzenellenbogen , Emily Henderson , University Of California , University Of Illinois At Urbana Champaign , Uc Riverside School Of Medicine , Multiple Sclerosis , Immune System , Mouse Model , Optic Neuritis , ஒன்றுபட்டது மாநிலங்களில் , ஆற்றங்கரை பள்ளி , சீமா திவாரி வூட்ரஃப் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் இல் ஊர்பன சாம்பியன் , அக் ஆற்றங்கரை பள்ளி ஆஃப் மருந்து , பல ஸ்க்லரோசிஸ் , நோய் எதிர்ப்பு சக்தி அமைப்பு , சுட்டி மாதிரி ,

Evolutionary history reveals the function of fish and human bitter receptors

Evolutionary history reveals the function of fish and human bitter receptors
To evaluate the chemical composition of food from a physiological point of view, it is important to know the functions of the receptors that interact with food ingredients. These include receptors for bitter compounds, which first evolved during evolution in bony fishes such as the coelacanth.
What 400 million years of evolutionary history reveal about the function of both fish and human bitter receptors was recently published in the journal
Genome Biology and Evolution by a team of researchers led by the Leibniz Institute for Food Systems Biology at the Technical University of Munich and the University of Cologne. ....

Sigrun Korsching , Maik Behrens , Emily Henderson , Technical University Of Munich , University Of Cologne , Leibniz Institute , Leibniz Institute For Food Systems Biology , Genome Biology , Food Systems Biology , Technical University , Antonella Di Pizio , எமிலி ஹென்டர்சன் , தொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் முனிச் , பல்கலைக்கழகம் ஆஃப் கொலோன் , மரபணு உயிரியல் , உணவு அமைப்புகள் உயிரியல் , தொழில்நுட்ப பல்கலைக்கழகம் ,

New platform using green algae tests for SARS-CoV-2 virus

Researchers at the University of California, San Diego, have demonstrated the potential of using green algae to make recombinant viral proteins that could be used in large scale assays to detect antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - the agent that causes coronavirus disease 2019 (COVID-19). ....

United States , San Diego , Sally Robertson , Stephen Mayfield , University Of California , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Polymerase Chain Reaction , Reverse Transcriptase , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , சான் டியாகோ , சாலி ராபர்ட்சன் , ஸ்டீபன் மேஃபீல்ட் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , கொரோனா வைரஸ் , எதிர் மின்னணு , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2

Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2
Among the hundred million or so cases of coronavirus disease 2019 (COVID-19) that have occurred since the pandemic began, pregnant women have been a conspicuous risk group. However, the exact nature of the risk they and their fetuses face, and the mechanism by which it operates, is far from clear. A new preprint research paper posted to the
medRxiv server throws some light on this area by revealing the presence of significant inflammation at the maternal-fetal interface.
Study: SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface. Image Credit: Natalia Grevtsova / Shutterstock ....

Liji Thomas , Natalia Grevtsova Shutterstock , Natalia Grevtsova , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Gene Expression , Immune Response , In Vitro , Pre Eclampsia , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , கொரோனா வைரஸ் , கீந் வெளிப்பாடு , நோய் எதிர்ப்பு சக்தி பதில் , இல் விட்ரோ , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,