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Study uncovers a novel promising target for diabetes treatment


Study uncovers a novel promising target for diabetes treatment
Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The latest study from Helmholtz Zentrum Muenchen, the Technical University of Munich and the German Center for Diabetes Research is a significant milestone for diabetes research as the scientific community celebrates 100 years of insulin and 50 years of insulin receptor discovery.
The blocking of inceptor function leads to an increased sensitization of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission.
Diabetes mellitus is a complex disease characterized by the loss or dysfunction of insulin-producing beta cells in the islets of Langerhans, a specialist micro-organ in the pancreas that controls systemic blood sugar levels. Diabetes complications, such as chronic high blood sugar, systemic metabolic failure and, in the long-te ....

Matthias Tsch , Frederick Banting , Heiko Lickert , Emily Henderson , Technical University Of Munich , Helmholtz Diabetes Center , Diabetes Research , German Center , Helmholtz Zentrum Muenchen , Technical University , Nobel Prize , Blood Sugar , Diabetes Mellitus , High Blood Sugar , Insulin Resistance , Signaling Pathway , ஃப்ரெடரிக் பைண்டிங் , எமிலி ஹென்டர்சன் , தொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் முனிச் , நீரிழிவு நோய் ஆராய்ச்சி , ஜெர்மன் மையம் , தொழில்நுட்ப பல்கலைக்கழகம் , நோபல் ப்ரைஸ் , நீரிழிவு நோய் , இரத்தம் சர்க்கரை , நீரிழிவு நோய் மெல்லிடஸ் ,

Study provides a detailed look at vulnerable sites on SARS-CoV-2


Study provides a detailed look at vulnerable sites on SARS-CoV-2
A new study led by scientists at La Jolla Institute for Immunology (LJI) suggests that T cells try to fight SARS-CoV-2 by targeting a broad range of sites on the virus beyond the key sites on the virus s spike protein. By attacking the virus from many angles, the body has the tools to potentially recognize different SARS-CoV-2 variants.
The new research, published January 27, 2021 in
Cell Report Medicine, is the most detailed analysis so far of which proteins on SARS-CoV-2 stimulate the strongest responses from the immune system s helper CD4+ T cells and killer CD8+ T cells. ....

United Kingdom , United States , San Diego , Alba Grifoni , Alessandro Sette , Emily Henderson , University Of California , Australia Murdoch University , Jolla Institute For Immunology , Coronavirus Task , Cell Report Medicine , Task Force , Sars Cov 2 , Immune Response , Immune System , Spike Protein , ஒன்றுபட்டது கிஂக்டம் , ஒன்றுபட்டது மாநிலங்களில் , சான் டியாகோ , Alessandro செத்தே , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , ஆஸ்திரேலியா முர்டோக் பல்கலைக்கழகம் , ஜொல்லா நிறுவனம் க்கு நோயெதிர்ப்பு , செல் அறிக்கை மருந்து , பணி படை ,

Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2


Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2
Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2, preventing expression of genes that encode proteins in cells such as resident macrophages in the nose and pulmonary alveoli, and epithelial cells lining the alveoli, all of which are entry points for the virus.
The hormone, therefore, prevents infection of these cells by the virus and inhibits the immune response so that the virus remains in the respiratory tract for a few days, eventually leaving to find another host.
The discovery by researchers at the University of São Paulo (USP), in Brazil, helps understand why some people are not infected or do not manifest symptoms of COVID-19 even when reliably diagnosed as carriers of the virus by RT-PCR. In addition, it offers the prospect of nasal administration of melatonin, in drops or as a spray, to prevent disease from developing in pre-symptomatic patients. ....

Marcos Buckeridge , Helder Nakaya , Regina Pekelmann Markus , Emily Henderson , Melatonin Research , Institute Of Biosciences , Journal Of Pineal Research , School Of Pharmaceutical Sciences , Pekelmann Markus , Principal Investigator , Pineal Research , Pharmaceutical Sciences , Gene Expression , Immune Response , Sars Cov 2 , வைத்திருப்பவர் நாகாய , எமிலி ஹென்டர்சன் , நிறுவனம் ஆஃப் உயிர் அறிவியல் , பள்ளி ஆஃப் மருந்து அறிவியல் , ப்ரிந்ஸிபல் புலனாய்வாளர் , மருந்து அறிவியல் , கீந் வெளிப்பாடு , நோய் எதிர்ப்பு சக்தி பதில் , மன அழுத்தம் ,