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Scientists discover mechanism for transient memory lapse

Scientists discover mechanism for transient memory lapse
In a landmark neurobiology study, scientists from Scripps Research have discovered a memory gating system that employs the neurotransmitter dopamine to direct transient forgetting, a temporary lapse of memory which spontaneously returns.
The study adds a new pin to scientists evolving map of how learning, memory and active forgetting work, says Scripps Research Neuroscience Professor Ron Davis, Ph.D.
This is the first time a mechanism has been discovered for transient memory lapse. There s every reason to believe, because of conservation biology, that a similar mechanism exists in humans as well.
Ron Davis, Ph.D., Neuroscience Professor, Scripps Research ....

United States , Jacob Berry , Ron Davis , John Martin Sabandal , Emily Henderson , Scripps Research , Scripps Research Neuroscience Professor Ron Davis , Neuroscience Professor , ஒன்றுபட்டது மாநிலங்களில் , ஜாகோப் பெர்ரி , ரோன் டேவிஸ் , எமிலி ஹென்டர்சன் , ஸ்கிரிப்ட்கள் ஆராய்ச்சி , ஸ்கிரிப்ட்கள் ஆராய்ச்சி நரம்பியல் ப்ரொஃபெஸர் ரோன் டேவிஸ் , நரம்பியல் ப்ரொஃபெஸர் ,

Researchers design armored immune cells to attack recurring cancer in liver transplant patients

Researchers design armored immune cells to attack recurring cancer in liver transplant patients
Duke-NUS Medical School researchers, together with collaborators in Singapore, have designed armored immune cells that can attack recurring cancer in liver transplant patients, while temporarily evading immunosuppressant drugs patients take to avoid organ rejection. The findings were published in the journal
Hepatology.
Hepatocellular carcinoma is the most common type of primary liver cancer and the sixth most common cancer worldwide. It often develops in people with chronic liver disease following hepatitis B infection.
A common treatment for hepatocellular carcinoma is to completely remove the liver and replace it with a healthy one from a donor. However, hepatitis B-related hepatocellular carcinoma can recur in some patients following transplantation. To kill the cancer, doctors can inject immune cells, called T cells, which are specially designed to target hepatitis ....

Patrick Casey , Antonio Bertoletti , Emily Henderson , Dean For Research , Infectious Diseases Programme , Professor Antonio Bertoletti , Emerging Infectious Diseases , Prof Bertoletti , Senior Vice Dean , Hepatitis B , Hepatocellular Carcinoma , Liver Cancer , Liver Disease , Liver Transplant , Medical School , பேட்ரிக் வழக்கு , எமிலி ஹென்டர்சன் , டீன் க்கு ஆராய்ச்சி , தொற்று நோய்கள் ப்ரோக்ராம் , வளர்ந்து வருகிறது தொற்று நோய்கள் , மூத்தவர் துணை டீன் , கல்லீரல் புற்றுநோய் , கல்லீரல் நோய் , கல்லீரல் மாற்று , மருத்துவ பள்ளி ,

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19
Researchers in China have conducted a study showing that a carbohydrate found in the seaweed
Ecklonia kurome blocks the activity of an enzyme that is essential for the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).
The seaweed – also called “Kun Bu” in China – has long been used as a medicinal plant in traditional Chinese medicine.
Kan Ding from the University of Chinese Academy of Sciences in Beijing and colleagues found that a crude polysaccharide extracted from the seaweed completely blocked the activity of an enzyme called 3C-like protease (3CLpro). ....

Sally Robertson , University Of Chinese Academy Sciences , Chinese Academy , Corona Virus , Coronavirus Disease Covid 19 , In Vitro , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , சாலி ராபர்ட்சன் , பல்கலைக்கழகம் ஆஃப் சீன கலைக்கழகம் அறிவியல் , சீன கலைக்கழகம் , கொரோனா வைரஸ் , இல் விட்ரோ , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Closed SARS-CoV-2 spikes could be a valuable component of future vaccines

Closed SARS-CoV-2 spikes could be a valuable component of future vaccines
As the coronavirus disease (COVID-19) pandemic continues to rage across the globe, many countries have rolled out vaccines. Populations to be vaccinated first are healthcare workers, front-liners, and high-risk individuals. The majority of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in use or advanced clinical development are based on the viral spike protein (S) as their immunogen.
Since the start of the pandemic, there are now 235 vaccine candidates for SARS-CoV-2. Of these, 172 vaccines are in pre-clinical evaluation, while 63 are undergoing human trials. Sixteen vaccines are in the last phase of human trials, with a handful receiving emergency use authorization. ....

United Kingdom , United States , Angela Betsaidab Laguipo , Research Council Laboratory Of Molecular Biology , Angela Betsaida , Medical Research Council Laboratory , Molecular Biology , Image Credit , Astrazeneca Chad , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Health Care , Medical Research , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது கிஂக்டம் , ஒன்றுபட்டது மாநிலங்களில் , ஆராய்ச்சி சபை ஆய்வகம் ஆஃப் மூலக்கூறு உயிரியல் , மருத்துவ ஆராய்ச்சி சபை ஆய்வகம் , மூலக்கூறு உயிரியல் , படம் கடன் , கொரோனா வைரஸ் , ஆரோக்கியம் பராமரிப்பு , மருத்துவ ஆராய்ச்சி ,

Two common blood pressure drugs are not tied to increased risk of COVID-19

Two common blood pressure drugs are not tied to increased risk of COVID-19
Research published in the peer-reviewed journal
The Lancet Digital Health and co-led by a UCLA Fielding School of Public Health faculty member has found that two widely used types of blood pressure drugs are not tied to an increased risk of COVID-19 infection or complications.
The international team co-led by Dr. Marc Suchard, UCLA Fielding School professor of biostatistics, found that there was no increased risk of COVID-19 diagnosis, hospitalization, or subsequent complications for users of either angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blockers (ARBs). The study, the world s largest, examined a group of more than 1.1 million patients in the United States and Spain using antihypertensives, researchers said. ....

United States , United Kingdom , Marc Suchard , George Hripcsak , Daniel Morales , Emily Henderson , Yale University , Observational Health Data Services , Columbia Department Of Biomedical Informatics , University Of Oxford , Columbia University , Fielding School Of Public Health , Lancet Digital Health , Fielding School Professor Of Biostatistics , Fielding School , Columbia Data Science Institute , University Of Dundee , Public Health , School Professor , Wellcome Trust , Columbia Department , Biomedical Informatics , Columbia Data Science , Blood Pressure , Ace Inhibitor , ஒன்றுபட்டது மாநிலங்களில் ,