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Researchers discover unexpected role for the clock gene in prostate cancer progression


Researchers discover unexpected role for the clock gene in prostate cancer progression
Our biological or circadian clock synchronizes all our bodily processes to the natural rhythms of light and dark. It s no wonder then that disrupting the clock can wreak havoc on our body. In fact, studies have shown that when circadian rhythms are disturbed through sleep deprivation, jet lag, or shift work, there is an increased incidence of some cancers including prostate cancer, which is the second leading cause of cancer death for men in the U.S.
With an urgent need to develop novel therapeutic targets for prostate cancer, researchers at the Sidney Kimmel Cancer - Jefferson Health (SKCC) explored the circadian clock and found an unexpected role for the clock gene CRY-1 in cancer progression. The study was published on January 15th in ....

Ayesha Shafi , Karen Knudsen , Emily Henderson , Nature Communications , Jefferson Health , Knudsen Lab , Sidney Kimmel Cancer , Study First Author , Postdoctoral Researcher , Prostate Cancer , Dna Damage , Jet Lag , ஆயிஷா ஷாஃபி , கரேன் நட்‌ஸெந் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , ஜெஃபர்சன் ஆரோக்கியம் , நட்‌ஸெந் ஆய்வகம் , சிட்னி கீம்மேல் புற்றுநோய் , படிப்பு முதல் நூலாசிரியர் , போஸ்ட்‌டாக்டொரல் ஆராய்ச்சியாளர் , ப்ராஸ்டேட் புற்றுநோய் , டீயெநே சேதம் , ஜெட் பின்னடைவு ,

New study can help determine effectiveness of chemotherapy in patients with bladder cancer


New study can help determine effectiveness of chemotherapy in patients with bladder cancer
In patients with bladder cancer, chemotherapy effectiveness is partially determined by the body s immune system response to the malignancy. This is the conclusion of research conducted by a team of scientists from Charité - Universitätsmedizin Berlin and the Berlin Institute of Health.
The findings, which have been published in
Science Translational Medicine, can be used to predict treatment success and may increase survival in patients with bladder cancer.
Bladder cancer is one of the ten most common types of cancer in Germany, and one of the five most common cancers in men. Nationwide, the disease affects approximately 30,000 people a year. The risk of cancer spreading (metastasizing) is particularly high once it invades the muscle layer inside the bladder wall. ....

Tino Vollmer , Michael Schm , Emily Henderson , Samir Sherif , Berlin Institute Of Health Center , Institute Of Medical Immunology , Berlin Center , Berlin Institute Of Health , Berlin Institute , Science Translational Medicine , Health Center , Regenerative Therapies , Medical Immunology , Advanced Therapies , Cancer Genome , Bladder Cancer , Immune System , டினோ வால்மர் , எமிலி ஹென்டர்சன் , அமீர் ஷெரிப் , பெர்லின் நிறுவனம் ஆஃப் ஆரோக்கியம் மையம் , நிறுவனம் ஆஃப் மருத்துவ நோயெதிர்ப்பு , பெர்லின் மையம் , பெர்லின் நிறுவனம் ஆஃப் ஆரோக்கியம் , பெர்லின் நிறுவனம் , அறிவியல் மொழிபெயர்ப்பு மருந்து ,

UH researcher working to identify potential new therapeutic targets for kidney disease


UH researcher working to identify potential new therapeutic targets for kidney disease
Among the primary forms of kidney disease, focal segmental glomerulosclerosis (FSGS) is the most common and is marked by high circulating levels of the suPAR protein (soluble urokinase-type plasminogen activator receptor). In the past year, high serum suPAR levels have also been found to predict kidney and multiple organ failure in hospitalized patients with COVID-19.
FSGS is a particularly insidious kidney disease. In many patients, it inexorably leads to kidney failure and we don t have much to offer to stop it, and worse still, in many patients it recurs after a kidney transplant, leading to failure of the transplanted kidney, said Stuart E. Dryer, Moores Professor of biology and biochemistry, who has a joint appointment as a professor of biomedical sciences in the UH College of Medicine. Dryer is working to identify potential new therapeutic targets for chronic kidney disease, espe ....

Emily Henderson , National Institute Of Diabetes , Uh College Of Medicine , Moores Professor , National Institute , Kidney Diseases , Kidney Disease , Focal Segmental Glomerulosclerosis , Oxidative Stress , எமிலி ஹென்டர்சன் , தேசிய நிறுவனம் ஆஃப் நீரிழிவு நோய் , இம் கல்லூரி ஆஃப் மருந்து , மூர்கள் ப்ரொஃபெஸர் , தேசிய நிறுவனம் , கிட்நீ நோய்கள் , கிட்நீ நோய் , உயிர் வேதியியல் , மன அழுத்தம் ,