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A snake venom enzyme shows anti-SARS-CoV-2 activity in vitro

A snake venom enzyme shows anti-SARS-CoV-2 activity in vitro
As the coronavirus disease 2019 (COVID-19) pandemic continues to infect people worldwide, specific pharmaceutical interventions have been found to be few. As the logistics of mass vaccination are still being ironed out, most public health measures across the globe still largely involve non-pharmaceutical interventions (NPIs) such as physical distancing, hand and face hygiene, mask-wearing, isolation of infected people and tracing of contacts.
Now, an interesting new study appearing on the
bioRxiv preprint server reports the virucidal and fusion-inhibiting attributes of snake venom against the COVID-19 agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ....

Liji Thomas , Dmitri Gomon Shutterstock , Dmitri Gomon , Middle East , Coronavirus Disease Covid 19 , In Vitro , Sars Cov 2 , Anti Fungal , Corona Virus , Public Health , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , நடுத்தர கிழக்கு , இல் விட்ரோ , எதிர்ப்பு பூஞ்சை , கொரோனா வைரஸ் , சர்வதேச பரவல் , பொது ஆரோக்கியம் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Antigenic "supersite" could improve design of COVID-19 vaccines

Researchers in the United States have defined an antigenic “supersite” within the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could have important implications for the design of vaccines to protect against coronavirus disease 2019 (COVID-19). ....

United States , Sally Robertson , Lawrence Shapiro , National Institute Of Allergy , Columbia University , National Institute , Infectious Diseases , Image Credit , Cell Membrane , Corona Virus , Coronavirus Disease Covid 19 , Electron Microscopy , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , சாலி ராபர்ட்சன் , லாரன்ஸ் ஷாபிரோ , தேசிய நிறுவனம் ஆஃப் ஒவ்வாமை , கொலம்பியா பல்கலைக்கழகம் , தேசிய நிறுவனம் , தொற்று நோய்கள் , படம் கடன் , செல் சவ்வு , கொரோனா வைரஸ் ,

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

One such strain is the South African 501.V2 and UK B1.1.7 strains, which have been isolated from many countries and seem to spread faster than the ancestral strain. A preprint that recently appeared on the bioRxiv server reports the computational structure of this strain and the possible effect of the mutations on infectivity and neutralization. ....

South Africa , United Kingdom , South African , Liji Thomas , Structure Based Computational , Image Credit , Corona Borealis Studio , Southern African , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது கிஂக்டம் , அமைப்பு அடிப்படையிலானது கணக்கீட்டு , படம் கடன் , கொரோனா போரியாலிஸ் ஸ்டுடியோ , பிணைப்பு இன உறவு , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Hypoxia signaling pathway could lead to COVID-19 treatments

Hypoxia signaling pathway could lead to COVID-19 treatments
Researchers in Spain have demonstrated that studying the hypoxia signaling pathway could provide opportunities for treating coronavirus disease 2019 (COVID-19).
The team conducted a study showing that hypoxic (oxygen-deficient) conditions reduced the expression of host cell receptors for the causative agent – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Hypoxic conditions reduced expression of angiotensin-converting enzyme 2 (ACE2) – the primary host cell receptor required for viral attachment and entry. They also decreased the expression of heparan sulfate (HS), another receptor known to be required for SARS-CoV-2 attachment.
The team – from the Basque Research and Technology Alliance in Derio and the Basque Foundation for Science in Bilbao also showed that hypoxia decreased HS levels through reduced expression of the main HS-containing proteoglycans (HSPGs) – syndecan-1 and synde ....

Pais Vasco , Sally Robertson , Basque Research , Technology Alliance In Derio , Basque Foundation For Science , Technology Alliance , Basque Foundation , Asis Palazon , Signaling Pathway , Angiotensin Converting Enzyme 2 , Cell Line , Corona Virus , Coronavirus Disease Covid 19 , Flow Cytometry , Gene Expression , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , பைஸ் வாஸ்கோ , சாலி ராபர்ட்சன் , பசியூ ஆராய்ச்சி , தொழில்நுட்பம் கூட்டணி இல் டெரியோ , பசியூ அடித்தளம் க்கு அறிவியல் , தொழில்நுட்பம் கூட்டணி , பசியூ அடித்தளம் ,

Researchers map genetic changes that may have facilitated SARS-CoV-2's jump from bats to humans

Researchers from the University of Cambridge and the Pirbright Institute in the UK have identified key genetic changes in SARS-CoV-2 that may be responsible for the virus’s jump from bats to humans. The team also determined which animals contain cellular receptors that allow the virus to enter cells more effectively, zoning in on potential animals that acted as an intermediary host in facilitating SARS-CoV-2’s zoonosis. ....

United States , United Kingdom , Saudi Arabia , Stephen Graham , Angela Betsaidab Laguipo , University Of Cambridge , University Of Cambridge Department Pathology , Pirbright Institute , Temple University , D Weblogo University Of California , Angela Betsaida , Wuhan City , Image Credit , Middle East Respiratory Syndrome , Sars Cov 2 , Amino Acid , Angiotensin Converting Enzyme 2 , Corona Virus , Mers Cov , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , சவுதி அரேபியா , ஸ்டீபன் கிரஹாம் ,