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Which SARS-CoV-2 mutations can potentially evade antibody recognition?

Which SARS-CoV-2 mutations can potentially evade antibody recognition?
To date, the coronavirus disease 2019 (COVID-19) pandemic has spread to 191 countries and infected more than 95.62 million people. Of these, more than 2 million people have lost their lives. The United States remains the nation with the highest number of cases, reaching 24 million, while India and Brazil follow, with over 10.58 million and 8.51 million cases, respectively.
New strains of the virus have begun to emerge with increased infectivity – including the VUI 202012/01 in Britain and 501.V2 in South Africa. This has led to concerns among public health authorities that mutant strains may evade neutralizing antibodies produced by convalescent individuals as well as the present vaccine candidates. ....

United States , South Africa , United Kingdom , Allison Greaney , Angela Betsaidab Laguipo , University Of Washington , Human Monoclonal Antibodiesa Properties , Vanderbilt University , Harvard Medical School , Fred Hutchinson Cancer Research Center , Angela Betsaida , Complete Mapping , Receptor Binding Domain , Escape Antibody , Image Credit , Cell Host Microbe , Escape Mutations , Monoclonal Antibodies , Complete Maps , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Public Health , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , அல்லிசன் கிரெஆநெய் ,

Study reveals possible SARS-CoV-2 escape mutant that may re-infect immune individuals

A recent study by US researchers shows how the 501Y.V2 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), characterized by several mutations, is able to escape neutralization by present first-wave anti-SARS-CoV-2 antibodies and potentially re-infect COVID-19 convalescent individuals. ....

South Africa , United States , United Kingdom , South African , Image Credit , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , படம் கடன் , பிணைப்பு இன உறவு , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?
The potentially deadly coronavirus disease 2019 (COVID-19) that has swept the world over the last 12 months has not affected animals with corresponding severity. In order to understand the mechanism of severe disease, animal models have been used. This includes a mouse model that expresses human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2). A new preprint appearing on the
bioRxiv server indicates that this may not be a faithful model of human lethal infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
In most cases, COVID-19 causes respiratory disease with a wide spectrum of symptom severity, from mild to severe. Critical disease usually terminates in acute respiratory distress syndrome (ARDS), often with multi-organ dysfunction. A subset of infected patients also have neurological features, including ....

Liji Thomas , Vasilii Koval Shutterstock Sars Co , Vasilii Koval Shutterstock , Vasilii Koval , Image Credit , Animal Model , Coronavirus Disease Covid 19 , Neurological Disease , Sars Cov 2 , Acute Respiratory Distress Syndrome , Angiotensin Converting Enzyme 2 , Central Nervous System , Corona Virus , Ischemic Stroke , Mouse Model , Nervous System , Respiratory Disease , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , படம் கடன் , விலங்கு மாதிரி , நரம்பியல் நோய் , எடுப்போசை சுவாச துன்பம் நோய்க்குறி , மைய பதட்டமாக அமைப்பு , கொரோனா வைரஸ் , சுட்டி மாதிரி ,

Study: Fibroblast hormone promotes movement of hematopoietic stem cells

Study: Fibroblast hormone promotes movement of hematopoietic stem cells
Discovery expected to contribute towards more effective methods of harvesting stem cells from bone marrow donors.
A Kobe University research group including graduate student ISHII Shinichi and Associate Professor KATAYAMA Yoshio (both of the Department of Hematology, Graduate School of Medicine) have discovered that fibroblast growth factor-23 (FGF23) produced by erythroblasts (cells that are the precursors of red blood cells) promotes the movement (mobilization) of hematopoietic stem cells into the peripheral blood.
Up until now, FGF23 has been known for the role it plays in the kidneys as a hormone that regulates phosphate concentrations throughout the body. ....

United States , Emily Henderson , Ya Kobe University , School Of Medicine , Department Of Hematology , Kobe University , Associate Professor , Graduate School , Bone Marrow , Bone Marrow Transplant , Growth Factor , Red Blood Cells , Stem Cells , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பள்ளி ஆஃப் மருந்து , துறை ஆஃப் ஹீமாட்டாலஜி , கோபி பல்கலைக்கழகம் , இணை ப்ரொஃபெஸர் , பட்டதாரி பள்ளி , எலும்பு மஜ்ஜை , எலும்பு மஜ்ஜை மாற்று , வளர்ச்சி காரணி , சிவப்பு இரத்தம் செல்கள் , தண்டு செல்கள் ,

A high-temperature tolerant SARS-CoV-2 derived immunogen as a potential vaccine candidate

There have been significant efforts worldwide to combat COVID-19, the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One prominent strategy has been to develop vaccines against the virus. Numerous vaccine candidates are under development, and a handful have now been approved for use by several countries. ....

Lakshmi Supriya , Phd Jan , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Immune Response , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , லட்சுமி சுப்ரியா , ஃப்ட் ஜான் , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,