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Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning

The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here we show successful noninvasive neuromodulation of the striatum via tTIS in humans using computational modeling, functional magnetic resonance imaging studies and behavioral evaluations. Theta-burst patterned striatal tTIS increased activity in the striatum and associated motor network. Furthermore, striatal tTIS enhanced motor performance, especially in healthy older participants as they have lower natural learning skills than younger subjects. These findings place tTIS as an exciting new method to target deep brain structures in humans noninvasively, thus enhancing our understanding of their functional role. Moreover, our results lay the groundwork for i ....

Zivari Adab , Almeida Marcelino , Trends Center , University Of Auckland , Boston University , Athinoulaa Martinos Center , Heinrich Heine University Dusseldorf , Brain Cogn , Brain Res , Brain Stimul , Neural Eng , Heine University Dusseldorf , Statistical Parametric Mapping , Biomedical Imaging , Res Methods , Power Analysis , Behavioral Sciences ,

Statistician I

Statistician IStatistician I: Support course evaluation activities. Reqs Master's in Stats, Applied Analytics, Educ Stats/Res Methods or eq 19614937 ....

University Of Southern California , United States , Los Angeles , Applied Analytics , Res Methods , Southern California ,