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An external validation study evaluates the performance of a prediction model in new data, but many of these studies are too small to provide reliable answers. In the third article of their series on model evaluation, Riley and colleagues describe how to calculate the sample size required for external validation studies, and propose to avoid rules of thumb by tailoring calculations to the model and setting at hand. External validation studies evaluate the performance of one or more prediction models (eg, developed previously using statistical, machine learning, or artificial intelligence approaches) in a different dataset to that used in the model development process.1 2 3 Part 2 in our series describes how to undertake a high quality external validation study,4 including the need to estimate model performance measures such as calibration (agreement between observed and predicted values), discrimination (separation between predicted values in those with and without an outcome event), o

United kingdomCity ofGarys collinsLucinda archerKym ie snellBen van calsterThomas pa debrayVan calsterRichardd rileyMaarten van smedenCare researchCancer research united kingdomResearch foundation flandersBirmingham biomedical research centreBetter methods researchSciences research council