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TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods

TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods
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Development and Validation of a Risk Score Predicting Death Without Transplant in Adult Heart Transplant Candidates | Surgery | JAMA

Evaluation of clinical prediction models (part 3): calculating the sample size required for an external validation study

An external validation study evaluates the performance of a prediction model in new data, but many of these studies are too small to provide reliable answers. In the third article of their series on model evaluation, Riley and colleagues describe how to calculate the sample size required for external validation studies, and propose to avoid rules of thumb by tailoring calculations to the model and setting at hand. External validation studies evaluate the performance of one or more prediction models (eg, developed previously using statistical, machine learning, or artificial intelligence approaches) in a different dataset to that used in the model development process.1 2 3 Part 2 in our series describes how to undertake a high quality external validation study,4 including the need to estimate model performance measures such as calibration (agreement between observed and predicted values), discrimination (separation between predicted values in those with and without an outcome event), o

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