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A decades-long friendship and a shared passion for basic science has inspired a $15 million gift to the Division of Biology & Biomedical Sciences (DBBS) at Washington University in St. Louis to fund undergraduate programs and graduate student fellowships in the life sciences.
/PRNewswire/ -- Harrington Discovery Institute at University Hospitals and Case Western Reserve University School of Medicine have issued a call for proposals...
/PRNewswire/ -- Harrington Discovery Institute at University Hospitals and Case Western Reserve University School of Medicine have issued a call for proposals...
P. Roy Vagelos, MD, and his wife, Diana Vagelos, are providing $15 million to support the university's Division of Biology & Biomedical Sciences. The gift will fund undergraduate and graduate efforts in the life sciences. The couple made the gift to honor former Chancellor William H. Danforth, MD, who died last year.
A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment by persistence or tolerance. Seeking mechanisms behind such high survival, we developed a forward-genetic method for efficient isolation of high-survival mutants in any culturable bacterial species. We found that perturbation of an essential biosynthetic pathway (arginine biosynthesis) in a mycobacterium generated three distinct forms of resistance to diverse antibiotics, each mediated by induction of WhiB7: high persistence and tolerance to kanamycin, high survival upon e...