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Impact of COVID-19 in Patients With Epilepsy: Higher Hospitalization, Death Rates

Compared with patients without epilepsy, those with epilepsy are at an increased risk for being hospitalized with and dying from COVID-19. ....

International Statistical Classification Of Diseases , Secure Anonymised Information Linkage , International Statistical Classification , Tenth Revision ,

Evaluation of clinical prediction models (part 2): how to undertake an external validation study

External validation studies are an important but often neglected part of prediction model research. In this article, the second in a series on model evaluation, Riley and colleagues explain what an external validation study entails and describe the key steps involved, from establishing a high quality dataset to evaluating a model’s predictive performance and clinical usefulness.

A clinical prediction model is used to calculate predictions for an individual conditional on their characteristics. Such predictions might be of a continuous value (eg, blood pressure, fat mass) or the probability of a particular event occurring (eg, disease recurrence), and are often in the context of a particular time point (eg, probability of disease recurrence within the next 12 months). Clinical prediction models are traditionally based on a regression equation but are increasingly derived using artificial intelligence or machine learning methods (eg, random forests, neural networks). Regardless ....

United Kingdom , Lucinda Archer , Lauraj Bonnett , Glenp Martin , Paula Dhiman , Richardd Riley , Kym Ie Snell , Garys Collins , University Of Birmingham , Duke Clinical Research Institute , Cancer Research United Kingdom , Better Methods Research , Health Improvement Network , Research Council , Sciences Research Council , United Kingdom Department Of Health , Birmingham Biomedical Research Centre , University Hospitals Birmingham , National Institute For Health , Clinical Practice Research Datalink , Care Research , Transparent Reporting , Individual Prognosis Or Diagnosis , United Kingdom Biobank , Risk Of Bias , Participant Selection ,

Association between perinatal mortality and morbidity and customised and non-customised birthweight centiles in Denmark, Finland, Norway, Wales, and England: comparative, population based, record linkage study

Objectives To compare the risk of adverse perinatal outcomes according to infants who are born small for gestational age (SGA; <10th centile) or large for gestational age (LGA; >90th centile), as defined by birthweight centiles that are non-customised (ie, standardised by sex and gestational age only) and customised (by sex, gestational age, maternal weight, height, parity, and ethnic group).

Design Comparative, population based, record linkage study with meta-analysis of results.

Setting Denmark, Finland, Norway, Wales, and England (city of Bradford), 1986-2019.

Participants 2 129 782 infants born at term in birth registries.

Main outcome measures Stillbirth, neonatal death, infant death, admission to neonatal intensive care unit, and low Apgar score (<7) at 5 minutes.

Results Relative to those infants born average for gestational age (AGA), both SGA and LGA births were at increased risk of all five outcomes, but observed relative risks were ....

United Kingdom , New Zealand , Health Research Ethics Of South East Norway , Information Governance Review Panel , Regional Committee For , Faculty Of Health , University Of Copenhagen , Danish Data Protection Agency , Medical Sciences , Danish Data , Statistics Finland Board , Personal Data Act , Statistics Finland , Regional Committee , Health Research Ethics , South East Norway , Secure Anonymised Information Linkage , Danish Registry ,

Children Receiving Care and Support in Wales Demonstrate Higher Immunization Rates

The research, published in Frontiers in Public Health, is the first data linkage study to explore vaccination coverage in children under social care services in Wales.The UK has a robust childhood immunisation programme that ensures children are offe ....

Borough Of Bedford , United Kingdom , Development Centre , Institute Of Child Health , Cardiff University , Professor Sally Holland University Of Cardiff , Grace Bailey Swansea University , National Community Child Health Database , Population Data Science At Swansea University , Children Social Care Research , Public Health Wales , Frontiers In Public Health , Public Health , Helen Bedford , Ormond Street Institute , Child Health , Children Receiving Care , Secure Anonymised Information Linkage , Grace Bailey , Swansea University , Professor Sally Holland , Population Data Science , Social Care Research ,

Welsh Children in Care More Prone to Immunisation: UCL Study

Welsh Children in Care More Prone to Immunisation: UCL Study
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United Kingdom , Borough Of Bedford , National Community Child Health Database , Public Health Wales , Children Social Care Research , Population Data Science At Swansea University , Frontiers In Public Health , Institute Of Child Health , Development Centre , University College London , Professor Sally Holland University Of Cardiff , Cardiff University , Grace Bailey Swansea University , University College , Public Health , Helen Bedford , Ormond Street Institute , Child Health , Children Receiving Care , Secure Anonymised Information Linkage , Grace Bailey , Swansea University , Professor Sally Holland , Population Data Science , Social Care Research ,