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Trimetazidine Reduces Cardiac Fibrosis in Rats by Inhibiting NOX2-Medi

Trimetazidine Reduces Cardiac Fibrosis in Rats by Inhibiting NOX2-Mediated Endothelial-to-Mesenchymal Transition ....

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[Full text] LINC00184 promotes OC proliferation and cisplatin resistance

Yuwen Han, Jun You, Yun Han, Yinglei Liu, Menghui Huang, Xiaoyan Lu, Jingjing Chen, Yanli Zheng
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, People’s Republic of China
Correspondence: Yanli Zheng
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nantong University, No. 6 North Hai-Er-Xiang Road, Chongchuan District, Nantong, 226001, Jiangsu Province, People’s Republic of China
Tel +86-0513-85061000
Objective: Cisplatin resistance is one of the main reasons for treatment failure in ovarian cancer (OC). Here, the effects of LINC00184 on cisplatin-resistant OC were studied.
Patients and Methods: LINC00184, miR-1305 and CNTN1 expression in tissues from 70 OC patients was determined by qRT-PCR, in situ hybridization and Western blot. OC cell lines and OC cisplatin-resistant cell lines were cultured. Cells were transfected using Lipofectamine 2000 an ....

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[Full text] miR-744-5p Inhibits Multiple Myeloma Proliferation, Epithelial Mesench

1
2Medical Records Management Division, Chongqing University Cancer Hospital, Chongqing, People’s Republic of China;
3Intensive Care Unit, Chongqing University Cancer Hospital, Chongqing, People’s Republic of China;
4Pharmacy Services, Chongqing University Cancer Hospital, Chongqing, People’s Republic of China
These authors contributed equally to this work
Correspondence: Dehong Huang
Department of Hematology and Oncology, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Chongqing, People’s Republic of China
Tel +86 23-65311341
Purpose: This study investigated the function and molecular mechanisms of miR-744-5p in multiple myeloma (MM).
Methods: miR-744-5p and SRY-related high-mobility-group box 12 (SOX12) expression in clinical tissues and MM cells was monitored by quantitative real-time polymerase chain reactions and Western blot. miR-744-5p expression in MM cells was regulated by transfection. Cell proliferation was resear ....

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