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Postpartum Low-Dose Esketamine Aids Moms With Prenatal Depression

A single low dose of esketamine after childbirth reduces depressive episodes at 42 days postpartum among mothers with prenatal depression.

Beijing , China , Peking , Shuo-wang , University-first-hospital , Healthday-news , Peking-university-first-hospital , Edinburgh-postnatal-depression-scale , Hamilton-depression-rating-scale ,

Postpartum low-dose esketamine aids moms with prenatal depression

Postpartum low-dose esketamine aids moms with prenatal depression
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

China , Edinburgh , City-of , United-kingdom , Beijing , Peking , British , Shuo-wang , University-first-hospital , Peking-university-first-hospital , Edinburgh-postnatal-depression-scale , Hamilton-depression-rating-scale

Tandem heatwaves, storm surges increasingly batter coasts: study

Paris (AFP) April 11, 2024 - Coastal communities need to prepare for simultaneous extreme weather events as heatwaves increasingly overlap with surges in sea levels due to climate change, a study published on Thursday warned.

Paris , France-general- , France , Hong-kong , United-states , America , Mo-zhao , Shuo-wang , Hong-kong-polytechnic-university , Communications-earth , West-africa , South-america

Tandem heatwaves and storm surges increasingly batter coasts: Study

This phenomenon that could multiply fivefold by the mid-century. Read more at straitstimes.com.

United-states , Hong-kong , America , Mo-zhao , Shuo-wang , Communications-earth-environment , Hong-kong-polytechnic-university , Communications-earth , South-east-asia , West-africa , South-america ,

Increased coastal threat from concurrent heat waves and sea level rise

Concurrent occurrences of heat waves and extreme short-term sea level rises at the same coastal locations significantly increased between 1998 and 2017 when compared to the preceding 20 years, reports a study.

Mo-zhou , Shuo-wang , Communications-earth-environment , Communications-earth , Northern-hemisphere ,

Heat and Floods Are Increasingly Hitting Coastlines with a One-Two Punch

Compound events in which coastal flooding and heat waves occur at the same time are happening more often as the planet warms

Louisiana , United-states , Hong-kong , Mo-zhou , Shuo-wang , Communications-earth-environment , Hong-kong-polytechnic-university , Communications-earth ,

MIL-OSI United Kingdom: expert reaction to clinical trial of low dose esketamine after childbirth for mothers with symptoms of prenatal depression

MIL-OSI United Kingdom: expert reaction to clinical trial of low dose esketamine after childbirth for mothers with symptoms of prenatal depression
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China , United-kingdom , Cambridge , Cambridgeshire , Shuo-wang , Camilla-nord , Drrupert-mcshane , University-of-oxford , Consultant-psychiatrist-at-oxford-health , Professor-at-department-of-psychiatry , Programme-leader , Brain-sciences-unit

Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial

Objective To determine whether a single low dose of esketamine administered after childbirth reduces postpartum depression in mothers with prenatal depression.

Design Randomised, double blind, placebo controlled trial with two parallel arms.

Setting Five tertiary care hospitals in China, 19 June 2020 to 3 August 2022.

Participants 364 mothers aged ≥18 years who had at least mild prenatal depression as indicated by Edinburgh postnatal depression scale scores of ≥10 (range 0-30, with higher scores indicating worse depression) and who were admitted to hospital for delivery.

Interventions Participants were randomly assigned 1:1 to receive either 0.2 mg/kg esketamine or placebo infused intravenously over 40 minutes after childbirth once the umbilical cord had been clamped.

Main outcome measures The primary outcome was prevalence of a major depressive episode at 42 days post partum, diagnosed using the mini-international neuropsychiatric interview. Secondary outcomes included the Edinburgh postnatal depression scale score at seven and 42 days post partum and the 17 item Hamilton depression rating scale score at 42 days post partum (range 0-52, with higher scores indicating worse depression). Adverse events were monitored until 24 hours after childbirth.

Results A total of 364 mothers (mean age 31.8 (standard deviation 4.1) years) were enrolled and randomised. At 42 days post partum, a major depressive episode was observed in 6.7% (12/180) of participants in the esketamine group compared with 25.4% (46/181) in the placebo group (relative risk 0.26, 95% confidence interval (CI) 0.14 to 0.48; P<0.001). Edinburgh postnatal depression scale scores were lower in the esketamine group at seven days (median difference −3, 95% CI −4 to −2; P<0.001) and 42 days (−3, −4 to −2; P<0.001). Hamilton depression rating scale scores at 42 days post partum were also lower in the esketamine group (−4, −6 to −3; P<0.001). The overall incidence of neuropsychiatric adverse events was higher in the esketamine group (45.1% (82/182) v 22.0% (40/182); P<0.001); however, symptoms lasted less than a day and none required drug treatment.

Conclusions For mothers with prenatal depression, a single low dose of esketamine after childbirth decreases major depressive episodes at 42 days post partum by about three quarters. Neuropsychiatric symptoms were more frequent but transient and did not require drug intervention.

Trial registration ClinicalTrials.gov [NCT04414943][1].

Anonymised individual patient data can be made available to researchers who provide a sound proposal and ethical approval, considering possible legal restrictions of China. Requests should be sent to corresponding author (wangdongxin@hotmail.com or dxwang65@bjmu.edu.cn).

[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04414943&atom=%2Fbmj%2F385%2Fbmj-2023-078218.atom

Peking , Beijing , China , Ming-jiang , Guangxi , Yuan-li , Fujian , United-states , Zhejiang , Liang-chen , Hainan , Edinburgh

Single Dose of Esketamine After Childbirth Reduces Postpartum Depression

A new study found a single low dose of esketamine given shortly after childbirth reduced major depressive episodes at 42 days postpartum by about 3 quarters.

China , Beijing , Peking , Shuo-wang , University-first-hospital , Peking-university-first-hospital , Postpartum-depression , Depression , Esketamine , Childbirth ,

Tandem heatwaves, storm surges increasingly batter coasts: study

Tandem heatwaves, storm surges increasingly batter coasts: study
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