Can You Take Tylenol, Ibuprofen After Having the COVID Vaccine? On 1/29/21 at 6:38 AM EST As COVID-19 vaccinations are rolled out across the country, you might be wondering if it is OK to take pain relievers before or after receiving a shot. After all, these vaccines can produce side effects that cause pain and discomfort, although they tend to be minor and should go away in a few days. The most common issues people will experience are pain and swelling at the injection site, while receivers may also experience fever, tiredness, chills or a headache. Read more For most people, health experts ...