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SARS-CoV-2, the COVID-19 virus, caused significant neuron damage and inflammation within a week of infection in rhesus macaque monkeys, according to a new study.
Monoclonal antibodies protected aged, diabetic rhesus macaque monkeys from disease due to SARS-CoV-2 and reduced signs of inflammation, including in
In the race to build the world’s first round of coronavirus vaccines, the spike protein—the thorny knobs that adorn each of the pathogen’s particles—was our MVP. Spike is a key ingredient in virtually every one of our current pandemic-fighting shots; it has been repeatedly billed as essential for tickling out any immune response worth its salt. “People put all their eggs in the spike basket,” Juliet Morrison, a virologist at UC Riverside, told me. And it undoubtedly paid off. In recent months, though, it’s become clear that the coronavirus is a slippery, shape-shifting foe—an...
E-Mail In a promising result for the success of vaccines against COVID-19, rhesus macaque monkeys infected with the human coronavirus SARS-CoV-2 developed protective immune responses that might be reproduced with a vaccine. The work was carried out at the California National Primate Research Center at the University of California, Davis and is published Jan. 22 in the journal Nature Communications. "These results suggest that vaccines inducing durable protective immunity against SARS-CoV-2 do so by stimulating robust germinal center responses - a question that can be effectively answered u...