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The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study

The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study
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City Of , United Kingdom , Global Lipids Genetics Consortium , Dr Isobel Stewart University Of Cambridge , Psychiatric Genomics Consortium , Mental Health Data Science Award , University Of Cambridge , Imperial College London , Department Of Health , Therapeutic Target Validation In Mental Health , University Of Bristol , Research Council , R Foundation For Statistical Computing , Doctoral Research Fellowship , Wellcome Trust Intermediate Clinical Fellowship , University Hospitals Bristol , Research Collaboration , National Institute For Health Research , Royal Society Grant Number , Biomedical Research Centre , Mental Health Data Pathfinder , Research In Genomic Epidemiology , Diabetes Genetics Replication And Meta Analysis , Genetic Investigation , Anthropometric Traits , Aging Research ,

Early Release - High Case-Fatality Rate for Human Anthrax, Northern Ghana, 2005–2016 - Volume 27, Number 4—April 2021 - Emerging Infectious Diseases journal

Our findings highlight the need for education about the risks of consuming meat from sick or dead animals and the benefits of livestock vaccination, increased healthcare provider awareness, and evaluation of accessibility to anthrax treatment. These findings support ongoing efforts in Ghana to coordinate human and livestock anthrax reporting and to improve and expand diagnostic capacity.
Dr. Blackburn is an associate professor of medical geography in global health and principal investigator at the Emerging Pathogens Institute, University of Florida. His research interests are focused on the spatiotemporal patterns and ecology of pathogens found in environmental reservoirs, particularly those that cause zoonoses. ....

Upper East , Upper East Region , Greater Accra , Northern Region , Talensi Nabdam , Pathogens Institute , Veterinary Services , Noguchi Memorial Institute For Medical Research , University Of Florida , West Africa , Upper West , North East , One Health , Ghanaian Ministries , Noguchi Memorial Institute , Medical Research , Statistical Computing , West Mamprusi , Bawku West , Emerging Pathogens Institute , Bacillus Anthracis , Case Fatality Rate , Cutaneous Anthrax , Enteric Infections , Food Safety , Gastrointestinal Anthrax ,

Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19

Three of the trials did not have study acronyms (only trial registration numbers) and ILBS-COVID-02 and PLACID did not have expansions in the original publications. ConCOVID indicates Convalescent Plasma as Therapy for Covid-19 Severe SARS-CoV-2 Disease; ConPlas-19, Convalescent Plasma Therapy vs SOC for the Treatment of COVID-19 in Hospitalized Patients; NA, not available; PICP19, Passive Immunization With Convalescent Plasma in Severe COVID-19 Disease; PlasmAr, Convalescent Plasma and Placebo for the Treatment of COVID-19 Severe Pneumonia; RECOVERY, Randomized Evaluation of COVID-19 Therapy.
aThere was no detailed information reported regarding (1) the randomization process or (2) the concealment of randomized assignment.
bThere was no detailed information reported regarding (1) the randomization process, (2) the concealment of randomized assignment, (3) the flow of patients through the trial, and (4) possible deviations from the intended interventions due to the open-la ....

United Kingdom , United States , Uppsala Lan , Larsg Hemkens , Uppsala University , America Foundation , National Center , Multifactorial Adaptive Platform Trial For Community , Alice Wallenberg Foundation , Research Innovation Center At Stanford University , John Arnold Foundation , University Hospital Basel , Association Of Convalescent Plasma With Clinical Outcomes , Swedish Society Of Medicine , Blanceflor Foundation , Swiss National Science Foundation , Department Of Clinical Research , R Foundation For Statistical Computing , Living Overview , Cochrane Risk , Bias Assessment , Recommendations Assessment , Emergency Use Authorization , Randomized Evaluation , Preferred Reporting Items , Systematic Review ,

[Full text] Mechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is

XYS Activates the PI3K/Akt Pathway
Network pharmacology suggested that the PI3k/Akt pathway was the main mechanism of action in IS treatment by XYS. Therefore, we evaluated the effect of XYS on the mRNA and protein expression of PI3k and Akt in PC12 cells. OGD/R inhibited mRNA expression of PI3K and Akt significantly in PC12 cells (Figures 9 and 10). Compared with the normal group, although protein expression of PI3K and Akt did not change significantly, phosphorylation of PI3K and Akt was inhibited significantly. Fortunately, XYS therapy could reverse this inhibition. These results indicated that the PI3k/Akt pathway was involved in the anti-IS action of XYS. ....

United States , Oliv Diels , Schwein Ryvarden Gilb , Professor Weiyin Chen Hospital Of Chengdu University , Thermo Fisher , Chengdu University , Beina Chuanglian Biotechnology Research Institute , Beckman Coulter , Interaction Network , Analysis Platform , Pubchem Compound , Chemical Book , Online Mendelian Inheritance , Treatment Targets Database , Protein Database , Search Tool , Discovery Studio , Statistical Computing , Roswell Park Memorial , Grand Island , Annexinv Fluorescein , Cell Counting Kit , Shengon Biotech , Boster Biological , Beijing Bioss Biotechnology , Small Molecule Compounds ,

Examining the Ugandan health system's readiness to deliver rheumatic heart disease-related services

Examining the Ugandan health system’s readiness to deliver rheumatic heart disease-related services
Emma Ndagire,
Roles
Formal analysis,
Writing – original draft,
Writing – review & editing
Affiliations
Uganda Heart Institute, Kampala, Uganda,
Children’s National Hospital, Division of Cardiology, Washington, District of Columbia, United States of America
⨯
Yoshito Kawakatsu,
Affiliation
Department of Global Health, University of Washington, Seattle, Washington, United States of America
Affiliation
Uganda Heart Institute, Kampala, Uganda
Affiliation
Uganda Heart Institute, Kampala, Uganda
Roles
Formal analysis,
Writing – review & editing
Affiliation
Children’s National Hospital, Division of Cardiology, Washington, District of Columbia, United States of America
⨯
Jafesi Pulle,
Affiliation
Uganda Heart Ins ....

University Of Washington , United States , Mbarara District , Northern Region , Antonio Luiz Ribeiro , Uganda Ministry Of Health , Uganda National Council For Science , American Heart Association , World Health Assembly , University Of Washington Human Subjects Division , Uganda Heart Institute , Service Availability , World Health Organization , Children National Hospital , Makerere University School Of Medicine Research , Ethics Committee , Organization Of Uganda , R Foundation For Statistical Computing , Member States , Creative Commons Attribution License , Uganda Ministry , Makerere University School , Medicine Research , Washington Human Subjects Division , Uganda National Council , Readiness Assessment ,