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Efficacy and Tolerability of Gefapixant for Treatment of Refractory or Unexplained Chronic Cough: A Systematic Review and Dose-Response Meta-Analysis | Otolaryngology | JAMA

This systematic review and dose-response meta-analysis evaluates the efficacy and tolerability of gefapixant, a new P2X3 antagonist, for the treatment of adults ....

United States , Ej Moran Campbell , Cochrane Ro , European Respiratory Society , European Medicines Agency , Department Of Medicine , Bellus Health , Cochrane Bias Methods Group , Faculty Of Health Sciences , American Academy Of Allergy , Mcmaster University Medical Centre , Canadian Lung Association , Mcmaster University , Canadian Institutes Of Health Research , American College Of Chest Physicians , Drug Administration , R Foundation For Statistical Computing , Health Canada , International Congress , Immunology Foundation , Faculty Development Award , Leicester Cough Questionnaire , Cochrane Central Register , Controlled Trials , Preferred Reporting Items , Systematic Reviews ,

Marine heatwaves are not a dominant driver of change in demersal fishes

Marine heatwaves have been linked to negative ecological effects in recent decades1,2. If marine heatwaves regularly induce community reorganization and biomass collapses in fishes, the consequences could be catastrophic for ecosystems, fisheries and human communities3,4. However, the extent to which marine heatwaves have negative impacts on fish biomass or community composition, or even whether their effects can be distinguished from natural and sampling variability, remains unclear. We investigated the effects of 248 sea-bottom heatwaves from 1993 to 2019 on marine fishes by analysing 82,322 hauls (samples) from long-term scientific surveys of continental shelf ecosystems in North America and Europe spanning the subtropics to the Arctic. Here we show that the effects of marine heatwaves on fish biomass were often minimal and could not be distinguished from natural and sampling variability. Furthermore, marine heatwaves were not consistently associated with tropicalization (gain of wa ....

North Sea , Oceans General , France General , United States , Le Grix , Pacific Ocean , Atmospheric Administration , Rr Core Team , Us South Atlantic Region National Oceanic , Change Biol , Alaska Pacific , World Fisheries , Remote Sens , Status Report , Atlantic Region , National Oceanic , Southern Gulf , Lawrence Atlantic Herring , Canadian Science Advisory Secretariat , West Hawai I , Special Report , Global Warming , Paris Agreement , Statistical Computing , Marine Species , Discrete Global ,

Screen Time at Age 1 Year and Communication and Problem-Solving Developmental Delay at 2 and 4 Years | JAMA Pediatrics

This cohort study examines the association between screen time exposure among children aged 1 year and developmental delay at age 2 and 4 years. ....

United States , Aoba Ku , Japan General , Taku Obara , Tohoku Medical Megabank Organization , Tohoku Medical Megabank Organization Institutional Review Board , Tohoku University , Japan Agency For Medical Research , American Academy Of Pediatrics , World Health Organization , Tohoku Medical Megabank Project Birth , Three Generation Cohort , Main Outcomes , Stages Questionnaires , World Health , American Academy , Cohort Study , Observational Studies , Statistical Computing , Population Characteristics , Logistic Regression Analysis , Screen Time , Developmental Delay Among Children , Interest Disclosures , Japan Agency , Medical Research ,

Smile-consistent basket skew

An analytic approximation for the implied volatility surface of basket options is introduced ....

Monte Carlo , Marco Avellaneda , Laurence Wang , Dan Pirjol , Bayer Laurence , Stevens Institute Of Technology , Communications In Pure , Communications On Pure , Stevens Institute , Applied Mathematics , Statistical Computing , Advanced Methods , Option Pricing , Financial Mathematics Series , Basket Options , Local Volatility Models , Implied Volatility , Volatility Surface , Option Pricing , Black Scholes , Cutting Edge ,

Predicting Hospital Readmission in Medicaid Patients With Diabetes Using Administrative and Claims Data

A statistical model based entirely on claims data can accurately predict 30-day hospital readmission in Medicaid patients with diabetes. ....

United States , New South Wales , Cox School , University Of Texas Southwestern Medical Center , Baylor University , Southern Methodist University , Amir Marashi , Kelly Dickson , Heroy Hall , Kathy Tannous , Peter Odonnell Jr , Harrell Fe Jr , Danielf Heitjan , Zhaoh Development , University Of Western Sydney , Model Development , Tissue Lab , Qual Manag Health Care , Hankamer School Of Business , Health Aff Millwood , Kidney Diseases Career Development Award , Boehringer Ingelheim , Hospital Readmissions Reduction Program , Department Of Internal Medicine , Spark Apache Software Foundation , International Classification Of Diseases ,