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A Big Hit, A Big Miss, & Mixed Vaccine Schedules: The 18-Month Mark Remember when we were told the earliest we could possibly hope for a vaccine was 12 to 18 months? Here we are, coming up on 18 months after the sequencing of the SARS-CoV-2 genome: people are calling vaccines with delivering results now “late”! And 15 vaccines have at least interim phase 3 results. While this was all going on, a group of documentary-makers were interviewing people in real time to tell the story as history unfolded. The results is called The Vaccine, and I hear it’s fantastic – try to catch it if it...

Absolutely Maybe We’ve well and truly reached cherry-picking season on Covid vaccine data! It’s definitely easier to fall into the trap of claims based on a biased selection of information – and harder to keep up with developments. With over 1 billion doses of Covid vaccines injected globally, the amount of datasets and studies is vast. Fortunately, there are now well over half a million people in phase 3 trials for Covid vaccines, providing an important base of critical information. That number could get close to a million in the coming months. A big thank you to everyone participatin...

Absolutely Maybe As results for the big phase 3 trials for the BNT-Pfizer and Moderna were looming, a debate ramped up: when would the thousands of people in their placebo groups get vaccinated? That debate got really intense when we saw how effective those vaccines looked, and how bad the Covid pandemic was getting. How do you weigh up the value of the critical information you would get from continuing the blinded trials – we only had very short-term efficacy and safety data when they delivered first results – versus not penalizing the group of people who had volunteered? If you didn’...

Absolutely Maybe It’s been another drama-filled, and data-packed, hectic few weeks in the Covid vaccines landscape. But the visual theme of this roundup post is the gigantic global airlift that’s underway at last, and the relief and hope that comes with it. There are the usual updates on the vaccines that have released efficacy results – and all the phase 3 trials that are underway, with over 460,000 participants so far. I’ve highlighted major community studies, too, the developments in combinations of vaccines, and trials in children and in pregnancy. And if after all that, you’d...

Absolutely Maybe We’re into the 12th month since sequencing of the genome of SARS-Cov-2, the virus that causes Covid-19. And we have 2 Covid vaccines across the line of convincing phase 3 trial results released, plus emergency use authorization or approval. How far are we now, and why did some sprint ahead while others fell behind? Let’s start with what we know from the handful of vaccines with at least some data released. Main takeaways about Covid vaccines so far There are important, often major, differences in the characteristics and effects of the vaccines. 2 vaccines have been convin...