Twisted DNA Increases CRISPR Off-target Effects
Understanding how Cas9 binds off-target sequences can help researchers refine CRISPR-mediated genome editing.
Source: the-scientist.com
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Epigenetic Therapy Reverses Endocrine-Resistant Breast Cancer Growth
Garvan researchers have revealed a reason why endocrine resistance develops in breast cancers and how to potentially treat it in patients.
Source: technologynetworks.com
Protein Shapes Indicate Parkinson's Disease | Technology Networks
Researchers have found that a set of proteins have different shapes in the spinal fluid of healthy individuals and Parkinson’s patients. These could be used in the future as a new type of biomarker for this disease.
Source: technologynetworks.com
Three-Step Mechanism Provides Defense Against Hepatitis B
Researchers have deciphered the precise mechanism that allows our body to defend itself against hepatitis B.
Source: technologynetworks.com
Frontiers | Commentary: Lethal Pneumonia Cases in Mojiang Miners (2012) and the Mineshaft Could Provide Important Clues to the Origin of SARS-CoV-2
Introduction It has been more than 1 year since the Covid-19 pandemic began in 2020 (1). The evolutionary origins of the SARS-CoV-2 virus can be partially traced to a lineage in bats; the closest known relative to SARS-CoV-2 (RaTG13) was found in a bat fecal sample taken from an abandoned mineshaft in Mojiang, China (2, 3). SARS-CoV-2 is proposed to have evolved via an intermediate host between bats and humans, or through natural selection in humans through direct contact with bats (2). Following a WHO-China investigation into the origins of the pandemic, a letter published in Science has poi...
Source: frontiersin.org