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2Department of Health Studies, FH Joanneum University of Applied Sciences, Graz, Austria Huntington’s disease (HD) is caused by an expansion of CAG triplets in the huntingtin gene, leading to severe neuropathological changes that result in a devasting and lethal phenotype. Neurodegeneration in HD begins in the striatum and spreads to other brain regions such as cortex and hippocampus, causing motor and cognitive dysfunctions. To understand the signaling pathways involved in HD, animal models that mimic the human pathology are used. The R6/2 mouse as model of HD was already shown to present ...

1Department of Oceanography and Fisheries, University of the Azores, Horta, Portugal 2Department of Biological Sciences and K.G. Jebsen Centre for Deep-Sea Research, University of Bergen, Bergen, Norway Few studies have described the effects of physical disturbance and post-recovery of deep-sea benthic communities. Here, we explore the status of deep-sea sponge ground communities four years after being impacted by an experimental bottom trawl. The diversity and abundance of epibenthic megafauna of two distinct benthic communities in disturbed versus control areas were surveyed using a remotel...

2Famine Early Warning Systems Network, Addis Ababa, Ethiopia 3Ethiopian Environment and Forest Research Institute (EEFRI), Addis Ababa, Ethiopia Long-term urban land use land cover change (LULCC) dynamics and climate change trends in Southwest Ethiopia's four urban centers were examined for 60 years. Remote sensing, aerial photos, and Landsat, temperature, and rainfall data were analyzed from a climate change perspective over the Jimma, Bedelle, Bonga, and Sokorru urban centers of southwest Ethiopia from 1953 to 2018. Based on geospatial analysis and maximum likelihood supervised image classi...

2Robert Schuman Centre for Advanced Studies, European University Institute, Florence, Italy The German citizenship law underwent a paradigmatic amendment in 2000. One often overlooked change of this reform was the abolishment of the domestic clause (“Inlandsklausel”) that implied a substantial restriction to de facto dual citizenship acceptance. Combining data from the German Socio-Economic Panel Study (waves 1993–2006) with original data on origin country policies on dual citizenship and citizenship reacquisition, we analyse the impact of the abolishment of the domestic clause on natur...

2Programa de Salud Familiar Comunitaria e Intercultural, Ministerio de Salud Bolivia, La Paz, Bolivia 3Hydrosciences Montpellier, Université de Montpellier, Institut de Recherche pour le Développement, Centre National de la Recherche Scientifique, Montpellier, France 4Genetics Institute, Universidad Mayor de San Andrés, La Paz, Bolivia Indigenous people living in the Bolivian Andes are exposed through their drinking water to inorganic arsenic, a potent carcinogen. However, the health consequences of arsenic exposure in this region are unknown. The aim of this study was to evaluate associat...