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Assessment of PET Depolymerization Processes for Circular Economy. 2. Process Design Options and Process Modeling Evaluation for Methanolysis, Glycolysis, and Hydrolysis

Assessment of PET Depolymerization Processes for Circular Economy. 2. Process Design Options and Process Modeling Evaluation for Methanolysis, Glycolysis, and Hydrolysis
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Loop Industries , Supporting Information ,

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract phospholipid oxidation1,2. Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected prosurvival function of its substrate, 7-dehydrocholesterol (7-DHC). Although previous studies suggested that high concentrations of 7-DHC are cytotoxic to developing neurons by favouring lipid peroxidation3, we now show that 7-DHC accumulation confers a robust prosurvival function in cancer cells. Because of its far superior reactivity towards peroxyl radicals, 7-DHC effectively shields (phospho)lipids from autoxidation and subsequent fragmentation. We provide validation in neuroblastoma and Burkitt’s lymphoma xenografts where we demonstrate that the accumulation of 7-DHC is capable of inducing a shi ....

Supporting Information , Multiple Myeloma ,

The benefits of sharing your data in a repository - The Official PLOS Blog

Purpose-built data repositories are the most effective, stable, and discoverable way to share research data which means more attention and impact for research. ....

Lauren Cadwallader , Open Data , Open Science , Open Access , Supporting Information ,