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MIT researchers discovered why the immune system mounts such a lackluster response to lung cancer, even after treatment with immunotherapy drugs: Bacteria naturally found in the lungs help create an environment that suppresses T-cell activation in the lymph nodes near the lungs.
Preventive and therapeutic vaccines both train the immune system to fight disease, but they are used in different ways.
Olfactory tissue biopsies help researchers discover the mechanism responsible for COVID-19-related loss of smell, along with other long COVID symptoms.
Exhausted T cells could work against the immune system, but scientists found that they can decrease the suppressive nature of these tired cells.
Immunotherapy has the potential to eliminate tumors, but works best for select patients. Engineering T cells to bypass cancer’s defenses could help expand treatment eligibility to more patients.