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Decreasing blood supply use could also preserve blood products for patients undergoing cancer treatment or surgery and for those with trauma or other illnesses.

Compared with a single dose, more patients in the split-dose group had improved disease activity at 16 weeks, and fewer needed additional DMARDs, but the effect was not found at 24 weeks.

Although the primary outcome was not statistically different between a liberal and more restrictive transfusion strategy, secondary results suggest some advantages for the liberal approach.

The approval allows for continuous immunotherapy treatment around surgery for resectable non-small cell lung cancer.