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Simulating evolution to understand a hidden switch

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IMAGE: Using computer simulations built on reasonable assumptions and conducted under careful control, computational bioscientists can mimic real biological conditions. Starting with the original founding population (ancient phase), they can evolve.
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Credit: © 2021 KAUST; Anastasia Serin
Computer simulations of cells evolving over tens of thousands of generations reveal why some organisms retain a disused switch mechanism that turns on under severe stress, changing some of their characteristics. Maintaining this hidden switch is one means for organisms to maintain a high degree of gene expression stability under normal conditions.
Tomato hornworm larvae are green in warmer regions, making camouflage easier, but black in cooler temperatures so that they can absorb more sunlight. This phenomenon, found in some organisms, is called phenotypic switching. Normally hidden, this switching is activated in response to dangerous genetic or ....

Xin Gao , Hiroyuki Kuwahara , Population Biology , Algorithms Models , Technology Engineering Computer Science , Computer Science , க்ஷின் கொ , உயிரி தொழில்நுட்பவியல் , பாப்யுலேஶந் உயிரியல் , தொழில்நுட்பம் பொறியியல் கணினி அறிவியல் , கணினி அறிவியல் , உயிர் தகவலியல் ,

Study: X-Rays surrounding 'Magnificent 7' may be traces of sought-after particle

A new study, led by a theoretical physicist at Berkeley Lab, suggests that never-before-observed particles called axions may be the source of unexplained, high-energy X-ray emissions surrounding a group of neutron stars. ....

United States , Ann Arbor , Benjamin Safdi , University Of California , Lawrencium Cluster At Berkeley Lab , Munich Institute For Astro , Draymond Co , National Science Foundation , University Of Michigan , European Space Agency Xmm Newton , Office Of Science , Research Computing , University Of Minnesota , Berkeley Lab Physics Division , Princeton University , Mainz Institute For Theoretical Physics , Lawrence Berkeley National Laboratory , Theory Department , Berkeley Lab , Divisional Fellow , Physical Review Letters , European Space Agency , Standard Model , Lawrencium Cluster , Energy Office , Science Early Career Research Program ,

A new tool to facilitate quicker, error-free software design

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Any building project requires the formulation of a series of initial plans prior to starting construction to serve as a basis and guide for the whole process. A similar procedure is followed in software development, with the inclusion of a specific step known as modelling. The process is equivalent to the production of a set of plans for a building before its construction, explained Universitat Oberta de Catalunya (UOC) Faculty of Computer Science, Multimedia and Telecommunications professor and member of the SOM Research Lab research group -from the Internet Interdisciplinary Institute (IN3)-, Robert Clarisó.
Engineers use modelling to describe a software system from a specific perspective, such as the data it will use, its components or the way they expect it to function. Going back to the building project example, the plans would be the models , which can be used for guidance during the development stage, as well as for carrying out simulations and tests. ....

Jordi Cabot , Robert Claris , Gran Telescopio Canarias , Carlosa Gonz , Sustainable Development Goal , Internet Interdisciplinary Institute , Innovation National Rdi Plan , Spanish Ministry Of Science , Software Engineering , Journal Of Object Technology , Spanish Network Of Excellence , Research Lab , Universitat Oberta De Catalunya , Computer Science , Unified Modelling Language , Object Technology , Spanish Network , Model Driven Software Engineering , Database Engineering Conference , Model Driven Software , Undertaking Project , Spanish Ministry , Technology Engineering Computer Science , ஜோர்டி காபொட் , ராபர்ட் கிளாரிஸ் , கிரான் தொலைநோக்கி கனாரியாக்கள் ,

Graduate student groups from 15 states awarded for science policy initiatives to engage

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Research!America and the Rita Allen Foundation are pleased to announce the recipients of the 2021 Civic Engagement Microgrant Initiative. Now in its third year, the microgrant program provides funding to graduate student and postdoc-led science policy groups from across the U.S. to develop and lead outreach activities in their local communities.
The 2021 Civic Engagement Microgrant Initiative is providing funding for 19 groups whose projects include podcasts, roundtable discussions, data visualization projects, and policy-orientated science fairs. Four grants will be used to start-up new groups. All activities will be conducted virtually due to the COVID-19 pandemic. Nearly 50 applications were received, a 50% increase from last year. The program is supported by a grant from the Rita Allen Foundation. ....

Stanford University , United States , San Diego , Mary Woolley , University Of California , Weill Cornell Medicine Center , University Of Nebraska Medical Center , University Of Pittsburgh School Medicine , University Of Michigan , University Of Missouri , University Of Massachusetts , Morgan State University , Rockefeller University , University Of South Carolina , Yale University School Of Medicine , Civic Engagement Microgrant Initiative , Baylor College Of Medicine , Microgrant Program , Ohio State University College Of Medicine , Virginia Polytechnic Institute , Boston University , University Of Georgia , American Physician Scientists Association , Rita Allen Foundation , Memorial Sloan Kettering Cancer Center , Engagement Microgrant ,

Chemotherapy with light; only one injection required

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IMAGE: A schematic diagram of the application of cancer-targeted supermolecular peptide phototherapy drugs to animal experiments developed by KIST researchers. A single supermolecular peptide phototherapy injection and repeated phototherapy were used.
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Credit: Korea Institute of Science and Technology(KIST)
Researchers in South Korea have developed a phototherapy technology that can significantly increase efficiency while reducing the pain of chemotherapy and minimizing side effects after treatment. The President of Korea Institute of Science and Technology (KIST), Seok-Jin Yoon announced that a research team led by Dr. Sehoon Kim at the Theragnosis Research Center (KU-KIST Graduate School of Converging Science and Technology) has developed a cancer-targeted phototherapeutic agent that promises complete elimination of cancer cells without side effects. It involves only one injection and repeated phototherapy. This development was made th ....

Soult Ukpyolsi , South Korea , Yoon Sik Lee , Dong June Ahn , Seokjin Yoon , Institutional Rd Program , Korea University , Theragnosis Research Center , Seoul National University , Korea Institute Of Science , School Of Converging Science , Ministry Of Science , Korea Institute , Se Hoon Kim , Converging Science , Professor Dong June Ahn , Professor Yoon Sik Lee , Seoul National , Director Se Hoon , Medicine Health , Technology Engineering Computer Science , தெற்கு கொரியா , யூன் சிக் லீ , டாங் ஜூன் அஹ்ன் , நிறுவன ர்ட் ப்ரோக்ர்யாம் , கொரியா பல்கலைக்கழகம் ,