Immunotherapy in Renal Cell Carcinoma
Analyzing the genomic and transcriptomic data from multiple ccRCC datasets, including bulk-RNA sequencing and single-cell RNA sequencing data.
Source: dovepress.com
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Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation
Cd86), were down-regulated in Mettl3-deficient cells (Fig. 1G), suggesting that METTL3 has a critical function in controlling the innate immune response of Raw 264.7 macrophages. To further confirm the biological role of the m 6A modification in macrophages, Mettl3 conditional KO (CKO) mice were generated by crossing Mettl3 flox/flox mice with mice expressing Cre recombinase under the control of lysozyme 2 promoter ( Lyzm-Cre). We have documented the loss of both the METTL3 protein and the overall m 6A modification in bone marrow–derived macrophages (BMDMs) from Mettl3 flox/flox; Lyzm-C...
Source: sciencemag.org