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New insight into how the occludin protein mediates cell-to-cell transmission of SARS-CoV-2 virus

While the coronavirus continues to infect people around the world, researchers at the University of Missouri have identified a specific protein inside the human body that plays a critical role in how the virus spreads from cell to cell after infection -; a discovery that will help better understand the COVID-19 disease and could lead to the development of new antiviral drugs in the future. ....

United States , R Michael Roberts , Heidi Liu , Liping Wang , Jialin Zhang , Emily Henderson , Sawrab Roy , Wenyu Yang , Wenjun Ma , Influenza Research , Mu School Of Medicine , University Of Missouri , Mu Laboratory For Infectious Disease Research , Mu College Of Veterinary Medicine , Research Foundation , National Institutes Of Health , Kansas University Medical Center , Centers Of Excellence , Veterinary Medicine , Infectious Disease , National Institutes , Peachtree Collaborative Orthomolecular Medicine , Covid 19 , Ars Cov 2 ,

Occludin protein plays key role in spread of

While the coronavirus continues to infect people around the world, researchers at the University of Missouri have identified a specific protein inside the human body that plays a critical role in how the virus spreads from cell to cell after infection a discovery that will help better understand the COVID-19 disease and could lead to the development of new antiviral drugs in the future.

The finding provides new insight into how the protein, known as the occludin protein, serves as a mediator for cell-to-cell transmission of the virus. ....

United States , Wenyu Yang , Jialin Zhang , R Michael Roberts , Heidi Liu , Wenjun Ma , Sawrab Roy , Liping Wang , Proceedings Of The National Academy Sciences , Mu College Of Veterinary Medicine , Research Foundation , National Institutes Of Health , Centers Of Excellence , Kansas University Medical Center , Mu Laboratory For Infectious Disease Research , Mu School Of Medicine , Influenza Research , Method Of Research , University Of Missouri , Veterinary Medicine , Infectious Disease , National Institutes , Peachtree Collaborative Orthomolecular Medicine , National Academy ,

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Scientists atSt. JudeChildren’s Research Hospital are working with colleagues in China to develop better therapy for childhood acute lymphoblastic leukemia (ALL). Results from a large phase 3 noninferiority clinical trial definitively showed that vincristine and dexamethasone pulses can be eliminated in patients with low-risk disease. The findings were published today in
The
Lancet Oncology.
Adding the chemotherapy vincristine plus a steroid (originally prednisone, and later dexamethasone) as pulse therapy for childhood ALL has been part of standard care since the 1970s. This is despite their being associated with neuropsychological side effects, neuropathy and other late effects. However, to date studies about the need for prolonged treatment with pulse therapy have been inconclusive. ....

Hong Kong , Hua Jiang , University Of Hong Kong , Hong Kong General , Hui Jiang , Hui Zhang , Jing Chen , Jingyan Tang , Aiguo Liu , Ju Gao , Yingchi Zhang , Wenyu Yang , Changda Liang , Minghua Yang , Kaili Pan , Runming Jin , Yongjun Fang , Chunfu Li , Yiping Zhu , Lirong Sun , Junj Yang , Jiaoyang Cai , Jie Yu , Xuedong Wu , Xiaowen Zhai , Ningling Wang ,