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Zongertinib Proves Clinically Active With Low Rate of EGFR-Mediated AEs in HER2-Mutant Solid Tumors

Treatment with at least 90 μg/kg of the novel DLLC-targeting T-cell–engager BI 764532 was well tolerated and led to tumor shrinkage in patients with small cell lung cancer and neuroendocrine carcinoma. ....

United States , Noboru Yamamoto , National Cancer Center Hospital , Department Of Experimental Therapeutics , Lung Cancer , Experimental Therapeutics , Middle East , World Conference On Lung Cancer , Her2 Mutant Solid Tumors , Zongertinib ,

Patritumab Deruxtecan Elicits Durable Responses in EGFR-Mutated NSCLC

Patritumab deruxtecan displayed clinically meaningful and durable efficacy in patients with advanced EGFR-mutated non–small cell lung cancer who experienced progression following treatment with an EGFR-directed TKI and platinum-based chemotherapy. ....

New York , United States , Memorial Sloan Kettering Cancer Center , Daiichi Sankyo , Helenaa Yu , Lung Cancer , Patritumab Deruxtecan , Non Small Cell Lung Cancer , Egfr Mutated Nsclc , Antibody Drug Conjugate , Her3 Dxd , Herthena Lung01 Trial , World Conference On Lung Cancer ,

Adagrasib Yields Durable Benefit for Patients With KRAS G12C–Mutant NSCLC

Adagrasib monotherapy provided durable efficacy for patients with KRAS G12C–mutated locally advanced or metastatic non–small cell lung cancer, according to 2-year follow-up data from the phase 1/2 KRYSTAL-1 trial.
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United States , Shirishm Gadgeel , Adagrasib Krazati , Henry Ford Cancer Institute In Detroit , Lung Cancer , Henry Ford Cancer Institute , North America , International Association , Kras G12c , Non Small Cell Lung Cancer , Krystal 1 Trial , World Conference On Lung Cancer ,