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Combination of deep brain stimulation and exercise has potential benefits for treating ataxia

Combination of deep brain stimulation and exercise has potential benefits for treating ataxia
New research from Baylor College of Medicine scientists shows that a combination of deep brain stimulation (DBS) and exercise has potential benefits for treating ataxia, a rare genetic neurodegenerative disease characterized by progressive irreversible problems with movement.
Working with a mouse model of the human condition, researchers at Baylor and the Jan and Dan Duncan Neurological Research Institute at Texas Children s Hospital discovered that combining DBS targeted to the cerebellum, a major motor center in the brain, and exercise rescued limb coordination and stepping and that the benefits persisted without further stimulation. ....

Roy Sillitoe , Lauren Miterko , Emily Henderson , Nature Communications , Baylor College Of Medicine , Baylor College , Dan Duncan Neurological Research Institute , Texas Children , Study First Author , Graduate Student , Neuropathology Core , Brain Stimulation , Deep Brain Stimulation , Mouse Model , Neurodegenerative Disease , Parkinson 39s Disease , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , பேலர் கல்லூரி ஆஃப் மருந்து , பேலர் கல்லூரி , டான் டங்கன் நரம்பியல் ஆராய்ச்சி நிறுவனம் , டெக்சாஸ் குழந்தைகள் , படிப்பு முதல் நூலாசிரியர் , பட்டதாரி மாணவர் , மூளை ஸ்டிம்யுலேஶந் , ஆழமான மூளை ஸ்டிம்யுலேஶந் ,

Scientists reveal the structure of glutamate transporter in our cells

Scientists reveal the structure of glutamate transporter in our cells
Feb 18 2021
For the first time, researchers have found one of the most important molecular machines in our cells uses a ‘twisting elevator’ mechanism, solving a mystery of how it transports crucial chemical signals from one cell to another.
Individual transporter particles captured by the cryo-EM (left), the structure solved by averaging thousands of these individual particles (middle) and a computer simulation of the glutamate transporter in a lipid membrane revealing the pathway for chloride ions (red) (right; image credit, Shashank Pant, University of Illinois at Urbana-Champaign)
A University of Sydney-led international team of scientists has revealed the shape of one of the most important molecular machines in our cells – the glutamate transporter – helping to explain how our brain cells communicate with one another. ....

United States , New South Wales , Ichia Chen , Qianyi Wu , Renae Ryan , University Of Illinois At Urbana Champaign , School Of Medical Sciences , University Of Sydney , Shashank Pant , Medical Sciences , Sydney Microscopy , Cell Membrane , Electron Microscopy , ஒன்றுபட்டது மாநிலங்களில் , புதியது தெற்கு வேல்ஸ் , ரெனே ரியான் , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் இல் ஊர்பன சாம்பியன் , பள்ளி ஆஃப் மருத்துவ அறிவியல் , பல்கலைக்கழகம் ஆஃப் சிட்னி , ஷாஷாங்க் பாண்ட் , மருத்துவ அறிவியல் , சிட்னி நுண்ணோக்கி , செல் சவ்வு , எதிர் மின்னணு , எதிர் மின்னணு நுண்ணோக்கி , வளர்சிதை மாற்றம் ,

Friedreich's Ataxia Market Analysis, Leading Companies, Emerging Drugs, and Epidemiology Forecast

(MENAFN - GetNews) DelveInsight s Friedreich s Ataxia Market Insights, Epidemiology, and Market Forecast 2030 report delivers an in-depth understanding of the Friedreich s Ataxia, historical and forecasted epidemiology as well as the Friedreich s Ataxia market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.
Friedreich s Ataxia (FA) is a rare autosomal recessive neurodegenerative disease that causes progressive nervous system damage and movement problems. It usually begins in childhood and leads to impaired muscle coordination (ataxia) that worsens over time. Most patients carry homozygous GAA expansions in the first intron of the frataxin gene on chromosome 9. Frataxin is a mitochondrial protein. Due to epigenetic alterations, frataxin expression is reduced significantly, and its deficiency leads to mitochondrial iron overload, defective energy supply, and generation of reactive oxygen species. ....

United States , United Kingdom , Shruti Thakur , Getnews Delveinsight Friedreich , Las Vegas , Takeda Pharmaceuticals , Reata Pharmaceuticals , Company Name , Market Research Firm , Delveinsight Business Research , National Institute Of Neurological Disorders , Ataxia Market Insights , Market Forecast , Ataxia Market Size , National Institute , Neurological Disorders , Ataxia Market Report , Ataxia Market , Unmet Needs , Ataxia Drugs Uptake , Key Market Players , Ataxia Drugs , Drugs Uptake , Ataxia Competitive Intelligence , Ataxia Market Overview , Ataxia Disease Background ,

£1.6 million grant awarded to advance development of MND drug candidate

£1.6 million grant awarded to advance development of MND drug candidate
Researchers from the University of Sheffield s Institute for Translational Neuroscience (SITraN) have been awarded a £1.6 million grant from the Medical Research Council (MRC). The grant will support their partnership with Aclipse Therapeutics to advance the translational development of M102 - a drug candidate for the treatment of motor neuron disease (MND).
Neuroprotective properties of M102 were discovered by SITraN researchers in 2013. Preclinical models evidenced the potential for M102 to slow down MND progression, which affects a patient s ability to walk, talk, eat and breathe.
The drug candidate activates the NRF2 (nuclear factor erythroid 2-related factor 2) and HSF1 (Heat shock factor 1) signalling pathways, which can work in combination to protect motor neurons from injury. ....

United Kingdom , Laura Ferraiuolo , Dame Pamela Shaw , Raymondk Houck , Richard Mead , Emily Henderson , Sheffield Biomedical Research Centre , Research Council , Translational Neuroscience , Medical Research Council , Aclipse Therapeutics , Professor Dame Pamela Shaw , Biomedical Research Centre , Amyotrophic Lateral Sclerosis , Friedreich 39s Ataxia , Huntington 39s Disease , Medical Research , Motor Neuron Disease , Motor Neurons , Parkinson 39s Disease , ஒன்றுபட்டது கிஂக்டம் , டேம் பமீலா ஷா , ரிச்சர்ட் மீட் , எமிலி ஹென்டர்சன் , ஷெஃபீல்ட் உயிர் மருத்துவ ஆராய்ச்சி மையம் , ஆராய்ச்சி சபை ,

Op-Ed: We Should Not Allow a Marijuana Free-for-All

Harms from cannabis are real they must be recognized and mitigated ....

United States , New Jersey , American Society Of Addiction Medicine , American Society , Addiction Medicine , Disorder Of Lung , Disorder Of Respiratory System , Coordination Problem , ஒன்றுபட்டது மாநிலங்களில் , புதியது ஜெர்சி , அமெரிக்கன் சமூகம் , கோளாறு ஆஃப் நுரையீரல் , கோளாறு ஆஃப் சுவாச அமைப்பு , ஒருங்கிணைப்பு ப்ராப்லம் ,