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New data for Roche's Hemlibra reinforce safety profile in people with haemophilia A


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Hemlibra is a bispecific factor IXa- and factor X-directed antibody. It is designed to bring together factor IXa and factor X, proteins involved in the natural coagulation cascade, and restore the blood clotting process for people with haemophilia A. Hemlibra is a prophylactic (preventative) treatment that can be administered by an injection of a ready-to-use solution under the skin (subcutaneously) once-weekly, every two weeks or every four weeks (after an initial once-weekly dose for the first four weeks). Hemlibra was created by Chugai Pharmaceutical Co., Ltd. and is being co-developed globally by Chugai, Roche and Genentech. It is marketed in the United States by Genentech as Hemlibra (emicizumab-kxwh), with kxwh as the suffix designated in accordance with Nonproprietary Naming of Biological Products Guidance for Industry issued by the U.S. Food and Drug Administration. ....

Glasgow City , United Kingdom , United States , Nathalie Meetz , Levi Garraway , Patrick Barth , Karsten Kleine , Chugai Pharmaceutical Co Ltd , International Society On Thrombosis , Drug Administration , Head Of Global Product Development , World Federation Of Hemophilia , Roche Group , Pharmaceuticals Industry , Roche Group Media Relations , World Congress , International Society , Chief Medical Officer , Global Product , Nonproprietary Naming , Biological Products Guidance , World Health Organization Model Lists , Essential Medicines , Dow Jones Sustainability Indices , Chugai Pharmaceutical , Trial Evaluating ,

F. Hoffmann-La Roche Ltd: New data for Roche's Hemlibra reinforce safety profile in people with haemophilia A


F. Hoffmann-La Roche Ltd: New data for Roche s Hemlibra reinforce safety profile in people with haemophilia A
IIIb
haemophilia
Hemlibra
1
STASEY is one of the largest open-label studies primarily assessing safety and tolerability of a medicine for people with
haemophilia
Hemlibra
also continued to demonstrate effective bleed control with a high proportion of participants (82.6%) achieving zero treated bleeds
1
Basel, 19 July 2021 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced results from the final analysis of the phase IIIb STASEY study, which confirm the favourable safety profile of Hemlibra (emicizumab), consistent with the phase III HAVEN clinical programme.
1,2,3,4 In the analysis, no new safety signals were identified with longer-term Hemlibra treatment in adults and adolescents with haemophilia A with inhibitors to factor VIII, the clotting protein that is missing or defective in people with haemophilia A. The data were pr ....

Glasgow City , United Kingdom , United States , Nathalie Meetz , Levi Garraway , Jon Kaspar Bayard , Karl Mahler , Mabthera Rituxan , Gazyva Gazyvaro , Sabine Borngr , Gerard Tobin , Bruno Eschli , Venclexta Venclyxto , Birgit Masjost , Loren Kalm , Patrick Barth , Karsten Kleine , Chugai Pharmaceutical Co Ltd , International Society On Thrombosis , Drug Administration , Head Of Global Product Development , World Federation Of Hemophilia , Roche Group , Pharmaceuticals Industry , Roche Group Media Relations , World Congress ,

Disease-modifying therapies for osteoarthritis


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Arch Phys Med Rehabil. 2021;102(1):115–131. doi:10.1016/j.apmr.2020.04.001
10. Puig-Junoy J, Ruiz Zamora A. Socio-economic costs of osteoarthritis: a systematic review of cost-of-illness studies.
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11. Leyland KM, Gates LS, Sanchez-Santos MT, et al. Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data. ....

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