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گلیکسو اسمتھ کلائن کی کووڈ ویکسین کے ٹرائل کے حوصلہ افزا نتائج - Health

گلیکسو اسمتھ کلائن کی کووڈ ویکسین کے ٹرائل کے حوصلہ افزا نتائج - Health
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Scientists unveil new Ebola virus vaccine design


Scientists unveil new Ebola virus vaccine design
Scientists at Scripps Research have unveiled a new Ebola virus vaccine design, which they say has several advantages over standard vaccine approaches for Ebola and related viruses that continue to threaten global health.
In the new design, described in a paper in
Nature Communications, copies of the Ebola virus outer spike protein, known as the glycoprotein, are tethered to the surface of a spherical carrier particle. The resulting structure resembles the spherical appearance of common RNA viruses that infect humans and is starkly different from the snake-like shape of the Ebola virus.
The scientists say the design is intended to stimulate a better protective immune response than standard vaccine approaches, which often expose the immune system to individual glycoproteins rather than realistic-looking virus particles. ....

Ian Wilson , Emily Henderson , Jiang Zhu , Scripps Research Institute , Nature Communications , Drug Administration , Department Of Integrative Structural , Scientists At Scripps Research , Scripps Research , Associate Professor , Integrative Structural , Computational Biology , West Africa , Hansen Professor , Structural Biology , Immune Response , Immune System , Spike Protein , T Cell , ஈயந் வில்சன் , எமிலி ஹென்டர்சன் , ஜியாங் ஜு , ஸ்கிரிப்ட்கள் ஆராய்ச்சி நிறுவனம் , இயற்கை தகவல்தொடர்புகள் , துறை ஆஃப் ஒருங்கிணைந்த கட்டமைப்பு , விஞ்ஞானிகள் இல் ஸ்கிரிப்ட்கள் ஆராய்ச்சி ,

Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials


Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials
The importance of computational modeling in the prediction of the course of the ongoing coronavirus disease 2019 (COVID-19) pandemic, as well as evaluating multiple potential drug leads, has never been more clear. Now, a new study describes a set of designer vaccine antigens that may improve vaccine stability as well as enhance the neutralizing antibody response.
The virus causing this pandemic is the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes an asymptomatic or mild infection in the vast majority, but spreads rapidly and extensively to produce a huge caseload in a relatively short period of time. This has led to overwhelming demands on healthcare services in many severely affected countries. ....

South Africa , South African , Liji Thomas , Protein Expression , Epitope Design , Coronavirus Disease Covid 19 , Ars Cov 2 , Spike Protein , Amino Acid , Computational Modeling , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , ப்ரோடீந் வெளிப்பாடு ,

NK cells combined with bispecific antibody display potent anti-tumor activity against lymphoma cells


NK cells combined with bispecific antibody display potent anti-tumor activity against lymphoma cells
Cytokine-activated natural killer (NK) cells derived from donated umbilical cord blood, combined with an investigational bispecific antibody targeting CD16a and CD30 known as AFM13, displayed potent anti-tumor activity against CD30+ lymphoma cells, according to a new preclinical study from researchers at The University of Texas MD Anderson Cancer Center.
The findings were published today in Clinical Cancer Research, a journal of the American Association for Cancer Research. These results led to the launch of a Phase I clinical trial to evaluate the combination of cord blood-derived NK cells (cbNK cells) with AFM13 as an experimental cell-based immunotherapy in patients with CD30+ lymphoma. ....

United States , Katy Rezvani , Emily Henderson , American Association For Cancer Research , University Of Texas Md Anderson Cancer Center , Md Anderson Cord Blood Bank , Clinical Cancer Research , American Association , Stem Cell Transplantation , Cord Blood Bank , Cancer Research , Bispecific Antibody , Clinical Trial , Umbilical Cord , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , மருத்துவ புற்றுநோய் ஆராய்ச்சி , அமெரிக்கன் சங்கம் , தண்டு செல் மாற்று அறுவை சிகிச்சை , தண்டு இரத்தம் வங்கி , புற்றுநோய் ஆராய்ச்சி ,