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FDA approves investigational monoclonal antibody therapy sotrovimab for COVID-19

FDA approves investigational monoclonal antibody therapy sotrovimab for COVID-19
The U.S. Food and Drug Administration (FDA) has given the green light on the investigational monoclonal antibody therapy, sotrovimab, as a treatment for coronavirus disease 2019 (COVID-19).
The regulatory agency granted an Emergency Use Authorization (EUA) for sotrovimab, previously called VIR-7831, to treat mild to moderate COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The therapy, which was developed by GlaxoSmithKline (GSK) and Vir Biotechnology, is a single-dose monoclonal antibody intended for adults and pediatric patients 12 years and above, weighing at least 40 kilograms.
What is a monoclonal antibody therapy?
Monoclonal antibodies are laboratory-made proteins that mimic the immune system’s ability to ward off harmful pathogens like viruses. ....

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Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

Researchers from the US tested the prophylactic potential of a combination of 2 mAbs administered 3 or 75 days before respiratory challenge in rhesus macaques. They used the rhesus macaque model to test the added benefit of combinatory parenteral administration of 2 high-affinity anti-SARS-CoV-2 mAbs - C144-LS and C135-LS. These mAbs were developed to neutralize the virus and tweaked to improve their pharmacokinetics. ....

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Research Suggests Mild COVID-19 Illness Leaves Behind Lasting Antibody Protection

Research Suggests Mild COVID-19 Illness Leaves Behind Lasting Antibody Protection
People who had mild COVID-19 have long-lasting antibody protection, according to a study by researchers from Washington University School of Medicine in St. Louis.
Scientists found that individuals who have recovered from a mild case of COVID-19 have long-lived plasma cells in their bone marrow that secretes low levels of antibodies against the CCP (Chinese Communist Party) virus for possibly a lifetime.
Plasma cells are a type of white blood cells developed from B cells and originate from the bone marrow. They are responsible for producing and secreting antibodies to a specific antigen. ....

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Different early antibody responses define COVID-19 disease trajectory

In a new study posted to the bioRxiv preprint server, a prospective cohort of patients with COVID-19 exhibited distinct features of the IgG fragment antigen-binding (Fab) and fragment crystallizable (Fc) domains, predicting two distinct disease trajectory two days after a positive test. ....

Susha Cheriyedath , Coronavirus Disease Covid 19 , Ars Cov 2 ,

B.1.617.2 variant of SARS-CoV-2 is partially resistant to antibody-mediated neutralization

A team of scientists from France has recently conducted a study to evaluate the sensitivity of the B.1.617 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to antibody-mediated neutralization. ....

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