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Frontiers | Excitatory Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex in a Guinea Pig Model Ameliorates Tinnitus


2School of Biological Sciences, University of Western Australia, Crawley, WA, Australia
3Perron Institute for Neurological and Translational Research, Crawley, WA, Australia
Tinnitus, a phantom auditory perception that can seriously affect quality of life, is generally triggered by cochlear trauma and associated with aberrant activity throughout the auditory pathways, often referred to as hyperactivity. Studies suggest that non-auditory structures, such as prefrontal cortex (PFC), may be involved in tinnitus generation, by affecting sensory gating in auditory thalamus, allowing hyperactivity to reach the cortex and lead to perception. Indeed, human studies have shown that repetitive transcranial magnetic stimulation (rTMS) of PFC can alleviate tinnitus. The current study investigated whether this therapeutic effect is achieved through inhibition of thalamic hyperactivity, comparing effects of two common clinical rTMS protocols with sham treatment, in a guinea pig tinnitus ....

New South Wales , Mecklenburg Vorpommern , United States , United Kingdom , Czech Republic , T Bruker Biospec , Entellan Merck Kga , Van Der Werff , Van Dijk , Meshfix Attene , Labchart Adinstruments , Biology Society , International Journal Of Neuropsychopharmacology , Ceva Animal Health , Mathworks Inc , Code Of The National Health , Merck Kga , Journal Of The Association For Research , Journal Of The Acoustical Society America , International Conference , Laboratory Animals , Wiley Online Library , University Of Western Australia , Research Council Of Australia , Elements Advanced Research , Proceedings Of The National Academy Sciences ,

Two existing drugs might be effective for sleep apnoea


While CPAP is an effective treatment for sleep apnoea, many find it too uncomfortable to use; effective drugs would greatly help this group of patients. TNS
Sleep apnoea is a condition where the upper airway from the back of the nose to the throat closes repetitively during sleep.
This results in a restriction of oxygen intake, causing people to wake as often as 100 times or more per hour.
Those with untreated sleep apnoea are more likely to develop cardiovascular disease, dementia and depression.
They are also two to four times more likely to crash a car than the general population, due to their fatigue from inadequate sleep. ....

South Australia , Danny Eckert , Research Council Of Australia , Neuroscience Research Australia , National Health , Flinders University Adelaide Institute For Sleep Health , Continuous Positive Airway Pressure , Flinders University Adelaide Institute , Sleep Health , Professor Danny Eckert , Prof Eckert , Medical Research Council , தெற்கு ஆஸ்திரேலியா , டேனி எக்கேற்ட் , ஆராய்ச்சி சபை ஆஃப் ஆஸ்திரேலியா , நரம்பியல் ஆராய்ச்சி ஆஸ்திரேலியா , தேசிய ஆரோக்கியம் , தொடர்ச்சியான பாஸிடிவ் காற்று வாங்கி ப்ரெஶர் , தூங்கு ஆரோக்கியம் , ப்ரொஃபெஸர் டேனி எக்கேற்ட் , மருத்துவ ஆராய்ச்சி சபை ,