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Researchers isolate human monoclonal antibodies that may neutralize several norovirus variants

Researchers isolate human monoclonal antibodies that may neutralize several norovirus variants
Researchers at Vanderbilt University Medical Center (VUMC) and the Baylor College of Medicine in Houston, Texas, have taken a big step toward developing targeted treatments and vaccines against a family of viruses that attacks the gastrointestinal tract.
Each year in the United States circulating strains of the human norovirus are responsible for approximately 20 million cases of acute gastroenteritis. Hallmark symptoms include severe abdominal cramping, diarrhea and vomiting.
Several vaccine candidates are in clinical trials, but it is unclear how effective they will be, given the periodic emergence of novel norovirus variants. Developing broadly effective vaccines will require an understanding of the genetic diversity of the virus and the mechanisms by which the immune system can neutralize it. ....

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Study identifies monoclonal antibodies that may neutralize many norovirus variants

Study identifies monoclonal antibodies that may neutralize many norovirus variants
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United States , Baylor College Of Medicine , Khalil Ettayebi , Gabriela Alvarado , James Crowe Jr , Ann Scott Carell , Wilhelm Salmen , Mary Estes , Alvin Romansky , Banumathi Sankaran , Bv Venkataram Prasad , Lawrence Berkeley National Laboratory In , Nature Communications , National Institute Of Allergy , National Institutes Of Health , Welch Foundation Of Houston , Researchers At Vanderbilt University Medical Center , Vanderbilt Vaccine Center , Vanderbilt University Medical Center , Baylor College , Alvin Romansky Chair , Cullen Chair , National Institute , Infectious Diseases , Ann Scott Carell Chair , Lawrence Berkeley National Laboratory ,

Study identifies monoclonal antibodies that may neutralize many norovirus variants

Study identifies monoclonal antibodies that may neutralize many norovirus variants
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United States , Baylor College Of Medicine , Khalil Ettayebi , Gabriela Alvarado , James Crowe Jr , Ann Scott Carell , Wilhelm Salmen , Mary Estes , Alvin Romansky , Banumathi Sankaran , Bv Venkataram Prasad , Lawrence Berkeley National Laboratory In , Nature Communications , National Institute Of Allergy , National Institutes Of Health , Welch Foundation Of Houston , Researchers At Vanderbilt University Medical Center , Vanderbilt Vaccine Center , Vanderbilt University Medical Center , Baylor College , Alvin Romansky Chair , Cullen Chair , National Institute , Infectious Diseases , Ann Scott Carell Chair , Lawrence Berkeley National Laboratory ,

Robert Siegel

Robert Siegel
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Researchers identify a common mechanism underlying diverse brain disorders

Researchers identify a common mechanism underlying diverse brain disorders
Researchers at Vanderbilt University Medical Center (VUMC) have identified a common mechanism underlying a spectrum of epilepsy syndromes and neurodevelopmental disorders, including autism, that are caused by variations in a gene encoding a vital transporter protein in the brain.
Their findings, reported last month in the journal
Brain, suggest that boosting transporter function via genetic or pharmacological means could be beneficial in treating brain disorders linked to these genetic variations.
This points to a clear direction of treating a wide spectrum of neurodevelopmental disorders, from various epilepsy syndromes (and) autism to neurodevelopmental delay and intellectual disabilities, caused by the pathological variants in this gene. ....

United States , Jing Qiong Katty Kang , Terry Jo Bichell , Emily Henderson , Researchers At Vanderbilt University Medical Center , Vanderbilt University Medical Center , Amber Freed , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , ஆராய்ச்சியாளர்கள் இல் வாண்டர்பில்ட் பல்கலைக்கழகம் மருத்துவ மையம் , வாண்டர்பில்ட் பல்கலைக்கழகம் மருத்துவ மையம் , அம்பர் விடுவிக்கப்பட்டது ,