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Study's findings may help eventually close door on COVID-19

By Bill Snyder Researchers at Vanderbilt University Medical Center and the University of Texas Medical Branch (UTMB) at Galveston have discovered what. ....

Mark Denison , Andrew Routh , Jennifer Gribble , Bill Snyder , Researchers At Vanderbilt University Medical Center , University Of Texas Medical Branch , Vanderbilt University Medical Center , Texas Medical Branch , Middle Eastern , Vanderbilt University , University Of Texas , Middle East , Corona Virus , Covid 19 , குறி மறுப்பு , ஆண்ட்ரூ ரூத் , ஜெனிபர் கசப்பு , ர சி து ஸ்னைடர் , ஆராய்ச்சியாளர்கள் இல் வாண்டர்பில்ட் பல்கலைக்கழகம் மருத்துவ மையம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் மருத்துவ கிளை , வாண்டர்பில்ட் பல்கலைக்கழகம் மருத்துவ மையம் , டெக்சாஸ் மருத்துவ கிளை , நடுத்தர கிழக்கு , வாண்டர்பில்ட் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் , உயிர் தகவலியல் ,

Viral ExoN regulates the rate of recombination in SARS-CoV-2

Viral ExoN regulates the rate of recombination in SARS-CoV-2
Researchers at Vanderbilt University Medical Center (VUMC) and the University of Texas Medical Branch (UTMB) at Galveston have discovered what may be the Achilles heel of the coronavirus, a finding that may help close the door on COVID-19 and possibly head off future pandemics.
The coronavirus is an RNA virus that has, in its enzymatic toolkit, a proofreading exoribonuclease, called nsp14-ExoN, which can correct errors in the RNA sequence that occur during replication, when copies of the virus are generated.
Using cutting-edge technologies and novel bioinformatics approaches, the researchers discovered that this ExoN also regulates the rate of recombination, the ability of the coronavirus to shuffle parts of its genome and even pull in genetic material from other viral strains while it replicates in order to gain evolutionary advantage. ....

Mark Denison , James Chappell , Andrea Pruijssers , Maria Agostini , Jennifer Gribble , Emily Henderson , Xiaotao Lu , Edward Claiborne Stahlman , Laura Stevens , Andrew Routh , Vanderbilt University Medical Center , Researchers At Vanderbilt University Medical Center , Study Co , Vanderbilt University School Of Medicine , University Of Texas Medical Branch , Division Of Pediatric Infectious Diseases , Texas Medical Branch , Middle Eastern , Molecular Biology , Pediatric Infectious Diseases , Jordan Anderson Daniels , Edward Claiborne Stahlman Chair , Pediatric Physiology , Cell Metabolism , Vanderbilt University School , Study Co Corresponding Author ,

Findings may help close door on COVID-19

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IMAGE: Jennifer Gribble, a graduate student in the laboratory of Mark Denison, MD, at Vanderbilt University Medical Center.
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Credit: Vanderbilt University Medical Center
Researchers at Vanderbilt University Medical Center (VUMC) and the University of Texas Medical Branch (UTMB) at Galveston have discovered what may be the Achilles heel of the coronavirus, a finding that may help close the door on COVID-19 and possibly head off future pandemics.
The coronavirus is an RNA virus that has, in its enzymatic toolkit, a proofreading exoribonuclease, called nsp14-ExoN, which can correct errors in the RNA sequence that occur during replication, when copies of the virus are generated. ....

United States , Vanderbilt University , Mark Denison , James Chappell , Andrea Pruijssers , Maria Agostini , Dolly Parton , Jennifer Gribble , Xiaotao Lu , Edward Claiborne Stahlman , Laura Stevens , Andrew Routh , Vanderbilt University Medical Center , National Institutes Of Health , University Of Texas Medical Branch , Division Of Pediatric Infectious Diseases , Elizabethb Lamb Center , Researchers At Vanderbilt University Medical Center , Vanderbilt University School Of Medicine , Pediatric Research At Vanderbilt , Research Fund , Texas Medical Branch , Middle Eastern , Molecular Biology , Pediatric Infectious Diseases , Jordan Anderson Daniels ,

Researchers identify genetic risk factors contributing to pneumonia susceptibility and severity

Researchers identify genetic risk factors contributing to pneumonia susceptibility and severity
Researchers at Vanderbilt University Medical Center and colleagues have identified genetic factors that increase the risk for developing pneumonia and its severe, life-threatening consequences.
Their findings, published recently in the
American Journal of Human Genetics, may aid efforts to identify patients with COVID-19 at greatest risk for pneumonia, and enable earlier interventions to prevent severe illness and death.
Despite the increasing availability of COVID-19 vaccines, it will take months to inoculate enough people to bring the pandemic under control, experts predict. In the meantime, thousands of Americans are hospitalized and die from COVID-19 each day. ....

United States , New York , Hsin Chen , Emily Henderson , Icahn School Of Medicine At Mount Sinai , University Of North Carolina At Chapel Hill , University Of Texas Md Anderson Cancer Center , Researchers At Vanderbilt University Medical Center , Vanderbilt University Medical Center , American Journal , Human Genetics , North Carolina , Chapel Hill , Cancer Center , Icahn School , Mount Sinai , Hung Hsin Chen , ஒன்றுபட்டது மாநிலங்களில் , புதியது யார்க் , ஹஸின் சென் , எமிலி ஹென்டர்சன் , இக்ஹ்ன் பள்ளி ஆஃப் மருந்து இல் ஏற்ற சினை , பல்கலைக்கழகம் ஆஃப் வடக்கு கரோலினா இல் தேவாலயம் மலை , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , ஆராய்ச்சியாளர்கள் இல் வாண்டர்பில்ட் பல்கலைக்கழகம் மருத்துவ மையம் , வாண்டர்பில்ட் பல்கலைக்கழகம் மருத்துவ மையம் ,

Study finds genetic clues to pneumonia risk and COVID-19 disparities

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IMAGE: Researchers at Vanderbilt University Medical Center and colleagues have identified genetic factors that increase the risk for developing pneumonia and its severe, life-threatening consequences.
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Credit: Vanderbilt University Medical Center
Researchers at Vanderbilt University Medical Center and colleagues have identified genetic factors that increase the risk for developing pneumonia and its severe, life-threatening consequences.
Their findings, published recently in the
American Journal of Human Genetics, may aid efforts to identify patients with COVID-19 at greatest risk for pneumonia, and enable earlier interventions to prevent severe illness and death.
Despite the increasing availability of COVID-19 vaccines, it will take months to inoculate enough people to bring the pandemic under control, experts predict. In the meantime, thousands of Americans are hospitalized and die from COVID-19 each day. ....

United States , New York , Julie Bastarache , Lisa Bastarache , Hsin Chen , Nancy Cox , Hannah Polikowsky , Megan Shuey , Douglas Shaw , Icahn School Of Medicine At Mount Sinai , University Of North Carolina At Chapel Hill , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Researchers At Vanderbilt University Medical Center , Vanderbilt University Medical Center , American Journal , Human Genetics , North Carolina , Chapel Hill , Cancer Center , Icahn School , Mount Sinai , Hung Hsin Chen , Lauren Petty , National Institutes , ஒன்றுபட்டது மாநிலங்களில் ,