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UNSW researchers find novel way to attack the 'fortress' surrounding pancreatic tumors


UNSW researchers find novel way to attack the fortress surrounding pancreatic tumors
May 17 2021
Tackling the scar tissue that shields pancreatic tumors from effective drug access is a promising advance in a notoriously hard-to-treat cancer.
Dr George Sharbeen and Associate Professor Phoebe Phillips in their lab. Photo: Richard Freeman / UNSW
UNSW medical researchers have found a way to starve pancreatic cancer cells and ‘disable’ the cells that block treatment from working effectively. Their findings in mice and human lab models – which have been 10 years in the making and are about to be put to the test in a human clinical trial – are published today in ....

United States , Phoebe Phillips , Joshua Mccarroll , Cyrille Boyer , Richard Freeman , George Sharbeen , Cancer Research , American Association For Cancer Research , University Of Queensland Professor Thomas Davis , Children Cancer Institute , Medicine Health , Associate Professor Phoebe Phillips , American Association , Associate Professor , Queensland Professor Thomas Davis , Associate Professor Joshua Mccarroll , Cancer Institute , Clinical Trial , Pancreatic Cancer , ஒன்றுபட்டது மாநிலங்களில் , ஃபோப் பிலிப்ஸ் , சிரில் பையன் , ரிச்சர்ட் ஃப்ரீமேன் , புற்றுநோய் ஆராய்ச்சி , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , குழந்தைகள் புற்றுநோய் நிறுவனம் ,

Scientists show how to attack the 'fortress' surrounding pancreatic cancer tumours – India Education | Latest Education News India | Global Educational News


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UNSW medical researchers have found a way to starve pancreatic cancer cells and ‘disable’ the cells that block treatment from working effectively. Their findings in mice and human lab models – which have been 10 years in the making and are about to be put to the test in a human clinical trial – are published today in 
Cancer Research, a journal of the American Association for Cancer Research.
“Pancreatic cancer has seen minimal improvement in survival for the last four decades – and without immediate action, it is predicted to be the world’s second biggest cancer killer by 2025,” says senior author Associate Professor Phoebe Phillips from UNSW Medicine & Health. ....

New South Wales , United States , Phoebe Phillips , David Goldstein , Joshua Mccarroll , Cyrille Boyer , George Sharbeen , Australian Pancreatic Cancer Foundation , University Of Queensland Professor Thomas Davis , Cancer Institute , Cancer Research , Translational Program Grant , American Association For Cancer Research , Children Cancer Institute , Medicine Health , American Association , Associate Professor Phoebe Phillips , Queensland Professor Thomas Davis , Associate Professor Joshua Mccarroll , Professor David Goldstein , புதியது தெற்கு வேல்ஸ் , ஒன்றுபட்டது மாநிலங்களில் , ஃபோப் பிலிப்ஸ் , டேவிட் கோல்ட்ஸ்டைன் , சிரில் பையன் , ஆஸ்திரேலிய கணையம் புற்றுநோய் அடித்தளம் ,

Scientists show how to attack the 'fortress' surrounding pancreatic cancer tumors


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Credit: UNSW Sydney
UNSW medical researchers have found a way to starve pancreatic cancer cells and disable the cells that block treatment from working effectively. Their findings in mice and human lab models - which have been 10 years in the making and are about to be put to the test in a human clinical trial - are published today in
Cancer Research, a journal of the American Association for Cancer Research.
Pancreatic cancer has seen minimal improvement in survival for the last four decades - and without immediate action, it is predicted to be the world s second biggest cancer killer by 2025, says senior author Associate Professor Phoebe Phillips from UNSW Medicine & Health. ....

United States , Phoebe Phillips , David Goldstein , Joshua Mccarroll , Cyrille Boyer , George Sharbeen , Australian Pancreatic Cancer Foundation , University Of Queensland Professor Thomas Davis , Cancer Institute , Cancer Research , Translational Program Grant , American Association For Cancer Research , Children Cancer Institute , Medicine Health , American Association , Associate Professor Phoebe Phillips , Queensland Professor Thomas Davis , Associate Professor Joshua Mccarroll , Professor David Goldstein , ஒன்றுபட்டது மாநிலங்களில் , ஃபோப் பிலிப்ஸ் , டேவிட் கோல்ட்ஸ்டைன் , சிரில் பையன் , ஆஸ்திரேலிய கணையம் புற்றுநோய் அடித்தளம் , புற்றுநோய் நிறுவனம் , புற்றுநோய் ஆராய்ச்சி ,

New hope for Aussies living with pancreatic cancer


The team found a way to metabolically rewire tumours by targeting a protein called SLC7A11.
We found that switching off SLC7A11 in mice with pancreatic tumours directly killed pancreatic cancer cells, reduced the spread of tumour cells throughout their body and decreased the scar tissue fortress, said Dr George Sharbeen, a postdoc researcher who led the experimental work.
The promising results were mirrored in experiments using patient tumour samples.
Our latest advance means today I am the most optimistic and hopeful I have been in my career, said Associate Professor Phillips.
The anti-arthritis drug called sulfasalazine also blocks this protein and will now be repurposed for the Phase II clinical trial. ....

Phoebe Phillips , George Sharbeen , Associate Professor Phoebe Phillips , Associate Professor , ஃபோப் பிலிப்ஸ் , இணை ப்ரொஃபெஸர் ஃபோப் பிலிப்ஸ் , இணை ப்ரொஃபெஸர் ,