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Risk Factors for HIV sero-conversion in a high incidence cohort of men who have sex with men and transgender women in Bangkok, Thailand

Risk Factors for HIV sero-conversion in a high incidence cohort of men who have sex with men and transgender women in Bangkok, Thailand
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Krung Thep Mahanakhon , Kent Ford , United Kingdom , Walter Reed Army Institute Of Research , Thai National Guidelines , Community Advisory Boards , National Institute Of Allergy , Faculty Of Tropical Medicine At Mahidol University , Department Of Defense , Test Kit Lab , Us Army Medical Research , Funding Us National Institute Of Allergy , Us Army , Royal Thai Army , Us Department Of The Army , Royal Thai Army Clinical Research , Mahidol University , Development Command Military Infectious Diseases Research Program , Standard Diagnostics Inc , Ag Ab Combo Orgenics Ltd , Human Immunodeficiency , Transgender Women , Infectious Diseases , Thai Clinical Trials , Bangkok Men , Cohort Study ,

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells. This approach has led researchers to conclude that neutralizing antibodies (nAbs) primarily target the receptor-binding domain (RBD) of the virus s spike protein. Voss et al. took a different approach, using proteomic deconvolution of the serum immunoglobulin G antibody repertoire from four COVID-19 convalescent patients. They found that the nAb response was largely directed against epitopes such as the N-terminal domain (NTD), which lie outside the RBD. Several of these nAbs were shared among donors and targeted an NTD epitope that is frequently mutated by variants of concern.

Science , abg5268, this issue p. [1108][1]

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-Co ....

United States , San Francisco , University Of California , Lamontagne Center , Ut System Proteomics Network , National Institute Of Allergy , Department Of Defense , Infectious Diseases Research Program , Sauer Structural Biology Laboratory , Us Army , Research Institute Of Texas , University Of Texas Board Regents , Centers For Disease , National Institutes Of Health , Electron Microscopy Data Bank , Department Of The Army , Welch Foundation , Protein Data Bank , University Of Texas College Natural Sciences , Clayton Foundation , Ig Seq Lin , United Kingdom , Creative Commons Attribution , Infectious Disease , Military Infectious Diseases Research Program , Disease Control ,

Taiwan, frontline state in Cold War II

The free world must show that it’s able and willing to defend a small patch of free government. ....

United States , Taiwan Strait , Taiwan General , T Ai Pei , South Korea , South China Sea , Brunei General , Republic Of China , Robert Brown , Donald Trump , Henry Kissinger , Niall Ferguson , Franklin Roosevelt , Department Of Homeland Security , Centers For Disease , National Center , Infectious Diseases Research Program To Taipei , Emergency Management Agency , Us Army , American Legion , Cold War , West Berlin , President Tsai Ing Wen , Taichung Airport , Taiwan Relations Act , Marine Corps ,

Biotechnology Company Centivax Officially Launches

Biotechnology Company Centivax Officially Launches
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SAN FRANCISCO, April 29, 2021 /PRNewswire/ Centivax Inc. is proud to announce its launch on Jan. 1, 2021, as a fully independent biotechnology company developing broad-spectrum therapeutics and a vaccines portfolio, including indications in COVID-19, multi-drug resistant bacteria, influenza, antivenom and oncology. Our unusually mature portfolio of fully owned Centivax assets has been made possible by advanced computational immunoengineering technology platforms and intellectual property that enable Centivax to rapidly create the broad-spectrum antibodies and broad-spectrum vaccines clearly needed in 21st-century medicine, says Dr. Jacob Glanville, Founder and CEO of Centivax. It is these platforms that enable Centivax to enter clinical development of our first therapeutic within eight months of launch. ....

Nicholas Bayless , David Gangemi , Pamela Garzone , Jacob Glanville , Sawsan Youssef , David Tsao , Stephanie Wisner , Naval Medical Research Center , Walter Reed Army Institute Of Research , National Institute For Innovation , National Institute Of Health , Melinda Gates Foundation , Lab At University Of Kent , University Of San Francisco Biotechnology , Auburn University , Infectious Diseases Research Program , Kim Lab At Stanford University , Scripps Research Institute , Galveston National Labs , University Of Georgia , University Of San Carlos , Centivax Inc , Regulatory Affairs For Centivax , Technology Enterprise Consortium , Stanford University , Distributed Bio ,