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Stimulating Immune System to Fight Cancer

Max Planck scientists from Dortmund find immunoregulatory substances with newly developed test system
Cancer cells have evolved mechanisms to escape the body’s immune defense. Agents that prevent immune escape are attractive targets for the development of new cancer therapies. A group of scientists led by Herbert Waldmann and Slava Ziegler at the Max Planck Institute of Molecular Physiology in Dortmund has now developed a new cell-based test system to identify immunoregulatory modulators. Screening a library of over 150,000 substances revealed several potent substances with unprecedented structure.
384-well plate for the detection of potential Inhibitors.
© MPI of Molecular Physiology
Our immune system is very successful when it comes to warding off viruses and bacteria. It also recognizes cancer cells as potential enemies and fights them. However, cancer cells have developed strategies to evade surveillance by the immune system and to preven ....

Slava Ziegler , Herbert Waldmann , Max Planck , Elisabeth Hennes , Max Planck Institute , Molecular Physiology , Different Mechanisms , Max Planck Society , Immune Response , Clinical Trials , ஹெர்பர்ட் வால்ட்மேன் , மூலக்கூறு உடலியல் , நோய் எதிர்ப்பு சக்தி பதில் , மருத்துவ சோதனைகள் ,

What brings olfactory receptors to the cell surface

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Credit: Photo: C. Schranner / Leibniz-LSB@TUM
A team of scientists led by Dietmar Krautwurst from the Leibniz Institute for Food Systems Biology at the Technical University of Munich has now identified address codes in odorant receptor proteins for the first time. Similar to zip codes, the codes ensure that the sensor proteins are targeted from inside the cell to the cell surface, where they begin their work as odorant detectors. The new findings could contribute to the development of novel test systems with which the odorant profiles of foods can be analyzed in a high-throughput process and thus could be better controlled. ....

Nordrhein Westfalen , Gisela Olias , Dietmar Krautwurst , Hofmannt Angew , Technical University Of Munich , Leibniz Association , Leibniz Institute , Leibniz Institute For Food Systems Biology , Leibniz Research Museums , Public Relations , Food Systems Biology , Technical University , Leibniz Research , Leibniz Science Campuses , Leibniz Institutes , Cell Biology , Nutrition Nutrients , னோற்ர்ேன் வெஸ்ட்ஃபாலன் , தொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் முனிச் , பொது உறவுகள் , உணவு அமைப்புகள் உயிரியல் , தொழில்நுட்ப பல்கலைக்கழகம் , உயிர் வேதியியல் , உயிரி தொழில்நுட்பவியல் , செல் உயிரியல் , ஊட்டச்சத்து ஊட்டச்சத்துக்கள் ,

The trouble of being tall

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IMAGE: Giraffes are in general very alert and exploit their height advantage to scan the horizon using their excellent eyesight
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Credit: Mogens Trolle
The giraffe is a truly puzzling animal. With its exceptional anatomy and suite of evolutionary adaptations, the giraffe is an outstanding case of animal evolution and physiology. Now, an international team of researchers from the University of Copenhagen and Northwestern Polytechnical University in China have produced a high-quality genome from the giraffe and investigated which genes are likely to be responsible for its unique biological features.
The extraordinary stature of the giraffe has led to a long list of physiological co-adaptations. The blood pressure of the giraffe, for instance, is twice as high as in humans and most other mammals to allow a steady blood supply to the lofty head. How does the giraffe avoid the usual side effects of high blood pressure, such as severe dam ....

Rasmus Heller , Qiang Qiu , Northwestern Polytechnical University , University Of Copenhagen , Department Of Biology , Cell Biology , Ecology Environment , Population Biology , Zoology Veterinary Science , ரஸ்முச் ஹெல்லர் , கியாங் கீயூ , வடமேற்கு போள்யிட்டேச்ணிகள் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் கோபெந்ஹேகந் , துறை ஆஃப் உயிரியல் , செல் உயிரியல் , சூழலியல் சூழல் , பாப்யுலேஶந் உயிரியல் , ஸுவாலஜீ கால்நடை அறிவியல் , உயிர் தகவலியல் ,

Health promotion, prevention, and psychosocial health

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The promotion of psychosocial health among individuals, groups, and society is an increasingly important subject in the field of public health. Psychosocial health is a complex interaction between the psyche of an individual and the social environment in which that individual lives. Promoting psychosocial health is often challenging and complex for health care professionals. Therefore, an important question of public health significance is: how can we address and improve the psychosocial health of individuals, groups, as well as society in general?
An interdisciplinary team of specialists at the Department of Health Professions at the Bern University of Applied Sciences, Switzerland, have proposed action models based on the relationships between health promotion, prevention, and psychosocial health. The swiss team, led by Tannys Helfer have defined these concepts in relation to how they could be synergistically combined to promote psychosocial health. Understand ....

Tannys Helfer , Health Promotion , Department Of Health Professions , Bern University Of Applied Sciences , Psychosocial Health , Health Professions , Bern University , Applied Sciences , Pharmaceutical Sciences , Pharmaceutical Combinatorial Chemistry , Medicine Health , Pharmaceutical Science , Pharmaceutical Chemistry , Public Health , Rehabilitation Prosthetics Plastic Surgery , ஆரோக்கியம் ப்ரமோஶந் , துறை ஆஃப் ஆரோக்கியம் ப்ரொஃபெஶந்ஸ் , பெர்ன் பல்கலைக்கழகம் ஆஃப் பயன்படுத்தப்பட்டது அறிவியல் , உளவியல் ஆரோக்கியம் , ஆரோக்கியம் ப்ரொஃபெஶந்ஸ் , பெர்ன் பல்கலைக்கழகம் , பயன்படுத்தப்பட்டது அறிவியல் , மருந்து அறிவியல் , மருந்து ஆரோக்கியம் , மருந்து வேதியியல் , பொது ஆரோக்கியம் ,

Modernizing the naval selection process

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IMAGE: University of Houston psychologist Elena Grigorenko, is using sailors multidimensional profiles to fit the sailor to the proper job, and permit individualized Navy vocation counseling, decreasing the costs of unproductive.
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Credit: University of Houston
Recruiting and selecting the proper sailors for specific tasks in the U.S. Navy has proven tricky, with costs rising yearly as the military seeks to match sailors with appropriate specialties. A University of Houston professor of psychology and a team of collaborators is out to save the military money and streamline the process by developing a new personnel selection process, the Manpower and Personnel Assessment Battery (MPAB). ....

Lillie Cranz Cullen , Hugh Roy , Mcallister Quinn , Helena Grigorenko , Human Genetics Lab , Office Of Naval Research , Us Navy , University Of Houston , Personnel Assessment Battery , Lillie Cranz Cullen Distinguished Professor , Naval Research , Medicine Health , Social Behavioral Science , Mental Health , Decision Making Problem Solving , Stress Anxiety , Technology Engineering Computer Science , ஹக் ராய் , மக்யாலிஸ்டர் க்வின் , மனிதன் ஜெநெடிக்ஸ் ஆய்வகம் , அலுவலகம் ஆஃப் கடற்படை ஆராய்ச்சி , எங்களுக்கு கடற்படை , பல்கலைக்கழகம் ஆஃப் ஹூஸ்டன் , பணியாளர்கள் மதிப்பீடு மின்கலம் , கடற்படை ஆராய்ச்சி , மருந்து ஆரோக்கியம் ,