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Roadmaps of the brain reveal regions vulnerable to Alzheimers disease

Roadmaps of the brain reveal regions vulnerable to Alzheimers disease
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United States , Michaelx Henderson , Johnq Trojanowski , Modupef Olufemi , Ronaldj Gathagan , Eli Cornblath , Lakshmi Changolkar , Hannahj Brown , Danielles Bassett , Howardl Li , Alfredp Sloan Foundation , Stroke Of The National Institutes Health , National Science Foundation , Paulg Allen Foundation , Van Andel Institute Bioinformatics , University Of Pennsylvania , Catherinet Macarthur Foundation , Michaelj Fox Foundation For Parkinson Research , Michael Henderson Van Andel Institute , National Institute Of Neurological Disorders , Van Andel Institute , Science Advances , Bin Zhang , Biostatistics Core , National Institute , National Institutes ,

'Roadmaps' of the brain reveal regions vulnerable to Alzheimer's disease

Much like a supply truck crossing the countryside, the misfolded proteins that damage neurons in Alzheimer s disease travel the roads of the brain, sometimes stopping and sometimes re-routing to avoid roadblocks, reports a study published in Science Advances by researchers at Van Andel Institute and University of Pennsylvania. ....

United States , Michaelx Henderson , Johnq Trojanowski , Modupef Olufemi , Ronaldj Gathagan , Eli Cornblath , Lakshmi Changolkar , Hannahj Brown , Danielles Bassett , Howardl Li , Alfredp Sloan Foundation , Stroke Of The National Institutes Health , National Science Foundation , Paulg Allen Foundation , Van Andel Institute Bioinformatics , University Of Pennsylvania , Catherinet Macarthur Foundation , Michaelj Fox Foundation For Parkinson Research , National Institute Of Neurological Disorders , Van Andel Institute , Science Advances , Bin Zhang , Biostatistics Core , National Institute , National Institutes , Neurological Disorders ,

'Roadmaps' of the brain reveal regions vulnerable to Alzheimer's disease

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GRAND RAPIDS, Mich. (JUNE 10, 2021) Much like a supply truck crossing the countryside, the misfolded proteins that damage neurons in Alzheimer s disease travel the roads of the brain, sometimes stopping and sometimes re-routing to avoid roadblocks, reports a study published in
The findings shed light on how tau proteins, which form tangled clumps that damage brain cells in Alzheimer s, move through the brain. The study also provides new insights into why some areas of the brain are more vulnerable to damage than other areas.
While the interconnected structure of the brain is essential to its function, these misfolded proteins commandeer that structure to travel through the brain and cause progressive degeneration, said Michael X. Henderson, Ph.D., an assistant professor at Van Andel Institute and corresponding author of the study. By understanding how these proteins travel through the brain and what causes certain neurons to be at risk for damage, we c ....

United States , Michaelx Henderson , Johnq Trojanowski , Modupef Olufemi , Ronaldj Gathagan , Eli Cornblath , Lakshmi Changolkar , Hannahj Brown , Danielles Bassett , Howardl Li , Alfredp Sloan Foundation , Stroke Of The National Institutes Health , National Science Foundation , Paulg Allen Foundation , Van Andel Institute Bioinformatics , University Of Pennsylvania , Catherinet Macarthur Foundation , Michaelj Fox Foundation For Parkinson Research , National Institute Of Neurological Disorders , Van Andel Institute , Science Advances , Bin Zhang , Biostatistics Core , National Institute , National Institutes , Neurological Disorders ,

New study launched to more accurately diagnose early hepatocellular carcinoma

New study launched to more accurately diagnose early hepatocellular carcinoma
A first of its kind cohort study on patients at high risk of developing primary liver cancer also known as hepatocellular carcinoma (HCC), has been launched to diagnose HCC more accurately at an earlier stage and to predict an individual s likelihood of developing the cancer. HCC is the sixth most common cancer in the world but the third most common cause of cancer deaths globally. In Singapore, HCC is the third and fourth most common cause of cancer deaths, amongst males and females respectively.
While potentially curative treatment is possible with early diagnosis, only 20% of HCC cases are detected at a stage where cure is possible. This investigator-initiated multi-centre study led by the National Cancer Centre of Singapore (NCCS) called EarLy DEtection of HCC: miRNA, microbiome and imaGing biomArkers in the evolution of chroNiC livEr Disease in a high-risk prospective cohort (ELEGANCE), addr ....

National University Hospital , Singapore General , Marine Parade , Tan Tock Seng Hospital , Bukit Merah , Mihir Gandhi , Asia Pacific , Wang Yulan , Emily Henderson , Dan Yock Young , Jason Chang Pik , Centre For Quantitative Medicine , Division Of Gastroenterology , Agency Of Science , Lee Kong Chian School Of Medicine , National Cancer Centre Of Singapore , Nanyang Technological University Singapore , Singapore Phenome Centre , Department Of Gastroenterology Hepatology , National Cancer Centre Singapore , Division Of Surgery , Health Services Systems Research Signature Programme , National Cancer Centre , Pierce Chow , Principal Investigator , Senior Consultant ,

Landmark study launched to detect liver cancer early in Singapore

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IMAGE: Quantitative MR images of the liver from six patients presenting with liver cancer produced by Perspectum s LiverMultiScan which will be used in a new study led by National Cancer Centre.
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Credit: Image credit: Mole DJ et al. Plos One. 2020;15(12):e0238568
Only 20% of primary liver cancer or hepatocellular carcinoma (HCC) are diagnosed at an early stage, which makes early detection an urgent, unmet healthcare need.
Study aims to develop more accurate diagnostics for early HCC, an AI algorithm to predict an individual s risk of developing HCC, and discover novel molecular targets to prevent the development of HCC. ....

National University Hospital , Singapore General , Marine Parade , Tan Tock Seng Hospital , Bukit Merah , National University Of Singapore , City Of , United Kingdom , Dharshini Subbiah , Shireen Federico , Dan Yock Young , Wang Yulan , Jason Chang Pik , Mihir Gandhi , Asia Pacific , Perspectum Livermultiscan , Yu Zehan , Duke University School Of Medicine , National Registry Of Diseases Office , Nanyang Technological University , Agency Of Science , Lee Kong Chian School Of Medicine , National Institute Of Education , Department Of Gastroenterology Hepatology , Singapore Centre For Environmental Life Sciences Engineering , Division Of Surgery ,