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Baseline medication use is associated with COVID-19 severity in people with rheumatic diseases

Baseline medication use is associated with COVID-19 severity in people with rheumatic diseases
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

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Rituximab a Hazard in RA Patients With COVID


email article
Patients with rheumatoid arthritis (RA) treated with rituximab (Rituxan) or JAK inhibitors had more severe COVID-19 disease courses, analysis of data from a large registry found.
In an adjusted multivariate analysis compared with patients on tumor necrosis factor (TNF) inhibitors, those on rituximab had a fourfold higher risk for worse disease (OR 4.15, 95% CI 3.16-5.44), while those on JAK inhibitors had a twofold greater risk (OR 2.06, 95% CI 1.60-2.65), reported Jeffrey Sparks, MD, of Harvard Medical School in Boston, at the European League Against Rheumatism virtual congress.
As we all know, there has been intense interest during the pandemic in repurposing immune modulating drugs for COVID-19 treatment, he said. ....

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Methotrexate May Interfere With Covid-19 Vaccine


iStock (2)
Since the COVID-19 vaccine was authorized for use in the United States, people with rheumatoid arthritis (RA) and their doctors have had questions about whether the shots are as effective if they take common medications to control their disease.
People on immune-suppressing medications were excluded from the clinical trials. It has been unclear whether the vaccine behaves the same in someone on these drugs as it does in the healthy people studied in the trials.
Now, answers are starting to emerge, and it appears those concerns may have been warranted. A study published May 25 in the
Annals of the Rheumatic Diseases found that up to one-third of people taking methotrexate failed to achieve an adequate immune response to the shot. ....

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