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Depression in older adults undergoing hip fracture repair associated with delirium after surgery


Depression in older adults undergoing hip fracture repair associated with delirium after surgery
According to Johns Hopkins Medicine researchers, the same depressive symptoms may also signal Alzheimer’s disease in some elderly patients.
Credit: Getty Images
Newswise Screening for even mild depressive symptoms before hip fracture repair may be helpful in predicting which patients are at higher risk of developing delirium after emergency surgery, according to results of a new study by researchers from Johns Hopkins Medicine. The researchers say their findings also add to evidence that symptoms of depression and postoperative delirium may be an early indicator of Alzheimer’s disease, although those findings were not conclusive. ....

Johns Hopkins University , United States , United Kingdom , Vastra Gotalands Lan , Johns Hopkins Bayview Medical Center , Kaj Blennow , Paul Rosenberg , Geoffrey Kahn , Karin Neufeld , Henrik Zetterberg , Constantine Lyketsos , Siemens Healthineers , Sharon Inouye , Frederick Sieber , Johns Hopkins , Yuh Wang , Jeannie Marie Leoutsakos , Carol Chan , Us Centers For Disease , European Research Councils , Johns Hopkins University School Of Medicine , Swedish State Support For Clinical Research , United Kingdom Dementia Research Institute , Brain Biomarker Solutions In Gothenburg , Neuromodulation Ltd , Swedish Research Council ,

New study sheds light on potential pathophysiological mechanism underlying delirium


New study sheds light on potential pathophysiological mechanism underlying delirium
Delirium, a common syndrome among older adults, particularly in those who have recently undergone surgery, critically ill patients in the ICU, and in older patients with multiple health issues, is a form of acute confusion that is characterized by poor attention, disorientation, impaired memory, delusions, and abrupt changes in mood and behavior.
Moreover, patients who experience delirium are at increased risk of long term cognitive decline. Recently, clinicians and scientists have recognized that delirium is one of the first signs of COVID-19 infection in older patients and that it occurs frequently in patients with severe COVID-19 disease. ....

Edward Marcantonio , Sarinnapha Vasunilashorn , Towia Libermann , Emily Henderson , Department Of Epidemiology , Beth Israel Deaconess Medical Center , National Institute On , Systems Biology Center , Professor Of Medicine At Harvard Medical School , Harvard Medical School , Medical Sciences , Study First Author , Assistant Professor , Harvard Medical , Systems Biology , Public Health , Successful Aging , Elective Surgery , National Institute , Section Chief , General Medicine , Associate Professor , Alzheimer 39s Disease , Medical School , எட்வர்ட் மார்கன்டோனியோ , எமிலி ஹென்டர்சன் ,

Delirium, Dementia, and the Brain


Autumn 2019
The scenario is distressing: Your elderly parent is hospitalized and becomes confused, withdrawn, anxious, and not himself.
He may very well have delirium, a sudden change in mental status that is common, serious, and costly and often goes unrecognized. With proper attention, however, many cases of delirium can be prevented. “Delirium comes on acutely. Someone can be OK one day and totally out of it the next day,” says HMS Professor of Medicine Sharon Inouye, MD, MPH, of Beth Israel Deaconess Medical Center. An internationally known expert on delirium, she is also the Milton and Shirley F. Levy Family Chair and director of the Aging Brain Center at the Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife. ....

United States , Debra Bradley Ruder , Edward Marcantonio , Sharon Inouye , Beth Israel Deaconess Medical Center , National Institute On , Harvard Mahoney Neuroscience Institute , School Department Of Neurobiology , Harvard Medical School , Successful Aging , Elective Surgery , National Institute , Bradley Ruder , ஒன்றுபட்டது மாநிலங்களில் , டெப்ரா பிராட்லி முரட்டுத்தனம் , எட்வர்ட் மார்கன்டோனியோ , ஷரோன் இணௌஉயே , பெத் இஸ்ரேல் டேப்ககோணேஸ் மருத்துவ மையம் , தேசிய நிறுவனம் ஆன் , ஹார்வர்ட் மஹோனி நரம்பியல் நிறுவனம் , பள்ளி துறை ஆஃப் நரம்பியல் , ஹார்வர்ட் மருத்துவ பள்ளி , தேர்ந்தெடுக்கப்பட்ட அறுவை சிகிச்சை , தேசிய நிறுவனம் , பிராட்லி முரட்டுத்தனம் ,