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Yale Cancer Center Researchers Discover Common Mechanism Causing Autoimmune Disease and Blood Cancers


April 19, 2021
In a study by Yale Cancer Center, researchers report on the discovery of a common mechanism that promotes both autoimmune diseases and blood cancers, including the blood diseases Acute Lymphoblastic Leukemia (ALL), Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL). The results could help scientists better understand disease origin and progression in patients. The paper is published online today in the journal
Molecular Cell.
“Our findings are very exciting in the field of both autoimmune disease and cancer, as they illustrate how pathogenic cells can ‘mis-use’ machinery from related cell types to cause disease and protect themselves from elimination,” said Markus Müschen, MD, PhD, Director of the Center of Molecular and Cellular Oncology and Arthur H. and Isabel Bunker Professor of Medicine (Hematology) at Yale Cancer Center, and senior author of the study. ....

Eric Meffre , Teresa Sadras , National Cancer Institute , National Institutes Of Health , Leukemia Lymphoma Society , Yale Cancer Center , Paulg Allen Frontiers Group , V Foundation For Cancer Research , Mark Foundation For Cancer Research , Howard Hughes Medical Institute , Acute Lymphoblastic Leukemia , Chronic Lymphocytic Leukemia , Mantle Cell Lymphoma , Cellular Oncology , Isabel Bunker Professor , National Institutes , Outstanding Investigator Award , Lymphoma Society , Mark Foundation , Cancer Research , Frontiers Group , தேசிய புற்றுநோய் நிறுவனம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , லுகேமியா லிம்போமா சமூகம் , யேல் புற்றுநோய் மையம் , வ் அடித்தளம் க்கு புற்றுநோய் ஆராய்ச்சி ,

NCI Deputy Director Dinah Singer, Ph.D.


Dinah Singer, Ph.D.
NCI Deputy Director for Scientific Strategy and Development
As the National Cancer Institute’s (NCI) deputy director for scientific strategy and development, Dinah Singer, Ph.D., works closely with the NCI director and other deputy directors to carry out the institute’s mission. Prior to taking on this role in 2019, she served as director of NCI’s Division of Cancer Biology (DCB), a position she held for 20 years. 
As deputy director, Dr. Singer leads a number of key initiatives at NCI. In early 2020, as part of NCI’s response to the COVID-19 pandemic, she led the rapid creation of the Serological Sciences Network (SeroNet) to expand serological testing capacity and research to characterize the immune responses elicited by the SARS-CoV-2 viral infection. ....

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