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March SLAS Discovery explores COVID-19 drug therapies six months later

Oak Brook, IL - The March edition of
SLAS Discovery features the cover article, Therapeutic and Vaccine Options for COVID-19: Status After 6 Months of the Disease Outbreak by Christian Ogaugwu (Federal University Oye-Ekiti, Ekiti State, Nigeria ), Dawid Maciorowski, Subba Rao Durvasula, Ph.D., Ravi Durvasula, M.D., and Adinarayana Kunamneni, Ph.D. (Loyola University Medical Center, Maywood, IL, USA).
This cover article focuses on the therapeutic and vaccine options available against the novel coronavirus, roughly six months after the outbreak; because the COVID-19-related death toll worldwide had reached 500,000 in six months (and ballooned to over 2,000,000 at the time of publishing) the importance of options to temper the disease cannot be overemphasized. The article highlights the available treatment alternatives for mild and serious active cases of COVID-19 infections and explores the vaccine options that should aid to confer immunity to vaccinated individuals. In ....

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January issue of <i>SLAS Discovery</i>

January issue of
SLAS (Society for Laboratory Automation and Screening)
Oak Brook, IL - The January edition of
SLAS Discovery features the cover article, Cryo-EM: The Resolution Revolution and Drug Discovery by Taiana Maia de Oliveira, Ph.D., Lotte van Beek, Ph.D., Fiona Shilliday, Ph.D., Judit E. Debreczeni, Ph.D., and Chris Phillips, Ph.D., from AstraZeneca.
Cryo-EM, a fast-growing technique in the pharmaceutical industry, enables structure determination of sought-after targets such as large multiprotein complexes and membrane proteins that eluded other structural biology methods. The intricate interactions between compounds and proteins are crucial in accelerating the drug discovery process. The cover article reviews how the structural understanding gained through Cryo-EM is influencing drug discovery projects focused on TRP channels, GPCRs, ribosomes and other high value targets. ....

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