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Chickens and pigs with built-in genetic scissors


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Chickens and pigs with built-in genetic scissors
Genetically engineered animals provide important insights into the molecular basis of health and disease. Research has focused mainly on genetically modified mice, although other species, such as pigs, are more similar to human physiology. Researchers at the Technical University of Munich (TUM) have now generated chickens and pigs in which target genes in desired organs can be efficiently altered.
Researchers at the TUM have demonstrated a way to efficiently study molecular mechanisms of disease resistance or biomedical issues in farm animals. Not only are researchers now able to introduce specific gene mutations into a desired organ or even correct existing genes without having to create new animal models for each target gene, but also this development reduces the number of animals required for research. ....

Daniel Wise , Lutz Kettler , Eckhard Wolf , Ibrahimt Hagag , Tatiana Flisikowska , Barbara Kessler , Benjamin Schusser , Beate Rieblinger , Nina Simm , Valeri Zakhartchenko , Mayuko Kurome , Krzysztof Flisikowski , Carolin Perleberg , Angelika Schnieke , Antonina Schlickenrieder , Jim Kaufman , Tarik Bozoglu , Christian Kupatt , Denise Duda , Romina Klinger , Harald Luksch , Hicham Sid , Alessandro Grodziecki , Technical University Of Munich , Technical University , Reproductive Biotechnology ,

Chickens and pigs with integrated genetic scissors


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IMAGE: Scientists at TUM have created chickens and pigs with integrated genetic scissors. This can be used at all stages of the animals development. They have already demonstrated applications in chicken.
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Credit: A. Heddergott / TUM
Researchers at the TUM have demonstrated a way to efficiently study molecular mechanisms of disease resistance or biomedical issues in farm animals. Researchers are now able to introduce specific gene mutations into a desired organ or even correct existing genes without creating new animal models for each target gene. This reduces the number of animals required for research..
CRISPR/Cas9 enables desired gene manipulations ....

Benjamin Schusser , Angelika Schnieke , Reproductive Biotechnology , Livestock Biotechnology , Medicine Health , Biomedical Environmental Chemical Engineering , இனப்பெருக்கம் உயிரி தொழில்நுட்பவியல் , கால்நடைகள் உயிரி தொழில்நுட்பவியல் ,

David Julius and Ardem Patapoutian win the Frontiers of Knowledge Award in Biomedicine


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Credit: BBVA Foundation
The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone in this thirteenth edition to David Julius, from the University of California, San Francisco, and Ardem Patapoutian, from the Scripps Institute, La Jolla (United States), for identifying the receptors that enable us to sense temperature, pain and pressure.
Temperature, pain and pressure are part of our sense of touch, perhaps the least understood of the five main senses of humans, read the opening words of the citation. Julius and Patapoutian provided a molecular and neural basis for thermosensation and mechanosensation.
This line of research holds out exciting medical possibilities, because it sheds light on how to reduce chronic and acute pain associated with a range of diseases, trauma and their treatments. In fact, several pharmaceutical laboratories are working to identify molecules that act on these receptors with the aim of treati ....

New York , United States , United Kingdom , Los Angeles , San Francisco , Robert Francis Furchgott , Ardem Patapoutian , Celis Ibeas , Angelika Schnieke , Luis Mart , Dolores Gonz , Isabel Varela Nieto , David Julius , Dario Alessi , Robin Lovell , Ali Shilatifard , M Isabel Medina , Bruce Whitelaw , Department Of Cellular , Department Of Animal Sciences , Foundation Frontiers Of Knowledge , Genomics Institute Of The Novartis Research Foundation , National Advisory Neurological Disorders , Department Of Neuroscience , Neyra Institute Of Parasitology , Technical University Of Munich ,